(E)-7-Benzenesulfonyl-2-methyl-12-oxo-oxacyclododec-4-ene-7-carboxylic acid methyl ester

Base Information

Chemical Name:(E)-7-Benzenesulfonyl-2-methyl-12-oxo-oxacyclododec-4-ene-7-carboxylic acid methyl ester
CAS No.:68726-93-2
Molecular Formula:C₂₀H₂₆O₆S
Molecular Weight:394.489
Hs Code.:

Synonyms:(E)-7-Benzenesulfonyl-2-methyl-12-oxo-oxacyclododec-4-ene-7-carboxylic acid methyl ester

Suppliers and Price of (E)-7-Benzenesulfonyl-2-methyl-12-oxo-oxacyclododec-4-ene-7-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (E)-7-Benzenesulfonyl-2-methyl-12-oxo-oxacyclododec-4-ene-7-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of (E)-7-Benzenesulfonyl-2-methyl-12-oxo-oxacyclododec-4-ene-7-carboxylic acid methyl ester

There total 11 articles about (E)-7-Benzenesulfonyl-2-methyl-12-oxo-oxacyclododec-4-ene-7-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4509-90-4
5-bromovaleroyl chloride

: 68726-93-2
(E)-7-Benzenesulfonyl-2-methyl-12-oxo-oxacyclododec-4-ene-7-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / pyridine / CH₂Cl₂ / 1 h / Ambient temperature

2: 82 percent / dimethylsulfoxide / 1 h / Ambient temperature

3: 70.5 percent / zinc, acetic acid / dimethylformamide / 0.75 h / 0 °C

4: thionyl chloride / dimethylformamide / 4 h / 40 - 45 °C

5: 79 percent / pyridine / diethyl ether / 30 h / Heating

6: 1.) sodium hydride, 2.) 1,2-bis(diphenylphosphino)ethane / 2.) tetrakis(triphenylphosphine)palladium⁽⁰⁾ / 1,) THF, 0 deg C, 30 min; room temperature, 15 min, 2.) reflux

With pyridine; thionyl chloride; sodium hydride; acetic acid; 1,2-bis-(diphenylphosphino)ethane; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja00534a030

Reference yield:

: 2067-33-6
5-bromopentanoic acid

: 68726-93-2
(E)-7-Benzenesulfonyl-2-methyl-12-oxo-oxacyclododec-4-ene-7-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / 1.) room temperature, 45 min, 2.) 45 deg C, 2 h

2: 91 percent / pyridine / CH₂Cl₂ / 1 h / Ambient temperature

3: 82 percent / dimethylsulfoxide / 1 h / Ambient temperature

4: 70.5 percent / zinc, acetic acid / dimethylformamide / 0.75 h / 0 °C

5: thionyl chloride / dimethylformamide / 4 h / 40 - 45 °C

6: 79 percent / pyridine / diethyl ether / 30 h / Heating

7: 1.) sodium hydride, 2.) 1,2-bis(diphenylphosphino)ethane / 2.) tetrakis(triphenylphosphine)palladium⁽⁰⁾ / 1,) THF, 0 deg C, 30 min; room temperature, 15 min, 2.) reflux

With pyridine; thionyl chloride; sodium hydride; acetic acid; 1,2-bis-(diphenylphosphino)ethane; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja00534a030

Reference yield:

: 68726-89-6
6-benzenesulfonyl-6-carbomethoxyhexanoic acid

: 68726-93-2
(E)-7-Benzenesulfonyl-2-methyl-12-oxo-oxacyclododec-4-ene-7-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / dimethylformamide / 4 h / 40 - 45 °C

2: 79 percent / pyridine / diethyl ether / 30 h / Heating

3: 1.) sodium hydride, 2.) 1,2-bis(diphenylphosphino)ethane / 2.) tetrakis(triphenylphosphine)palladium⁽⁰⁾ / 1,) THF, 0 deg C, 30 min; room temperature, 15 min, 2.) reflux

With pyridine; thionyl chloride; sodium hydride; 1,2-bis-(diphenylphosphino)ethane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ja00534a030