(2S,3R,4S,5E,7S)-7-(3-[1-(tert-butyl)-1,1-dimethylsilyl]oxyphenyl)-1-(2,2-dimethyl-1,1-diphenylpropoxy)-7-methoxy-2,4-dimethyl-5-hepten-3-ol

Base Information

Chemical Name:(2S,3R,4S,5E,7S)-7-(3-[1-(tert-butyl)-1,1-dimethylsilyl]oxyphenyl)-1-(2,2-dimethyl-1,1-diphenylpropoxy)-7-methoxy-2,4-dimethyl-5-hepten-3-ol
CAS No.:1446347-56-3
Molecular Formula:C₃₈H₅₆O₄Si₂
Molecular Weight:633.031
Hs Code.:

Synonyms:(2S,3R,4S,5E,7S)-7-(3-[1-(tert-butyl)-1,1-dimethylsilyl]oxyphenyl)-1-(2,2-dimethyl-1,1-diphenylpropoxy)-7-methoxy-2,4-dimethyl-5-hepten-3-ol

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Chemical Property of (2S,3R,4S,5E,7S)-7-(3-[1-(tert-butyl)-1,1-dimethylsilyl]oxyphenyl)-1-(2,2-dimethyl-1,1-diphenylpropoxy)-7-methoxy-2,4-dimethyl-5-hepten-3-ol

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Technology Process of (2S,3R,4S,5E,7S)-7-(3-[1-(tert-butyl)-1,1-dimethylsilyl]oxyphenyl)-1-(2,2-dimethyl-1,1-diphenylpropoxy)-7-methoxy-2,4-dimethyl-5-hepten-3-ol

There total 7 articles about (2S,3R,4S,5E,7S)-7-(3-[1-(tert-butyl)-1,1-dimethylsilyl]oxyphenyl)-1-(2,2-dimethyl-1,1-diphenylpropoxy)-7-methoxy-2,4-dimethyl-5-hepten-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1446347-55-2
tert-butyl 3-[(1S)-1-methoxy-2-propenyl]phenoxydimethylsilane

: C₂₅H₃₆OSi

: 1446347-56-3
(2S,3R,4S,5E,7S)-7-(3-[1-(tert-butyl)-1,1-dimethylsilyl]oxyphenyl)-1-(2,2-dimethyl-1,1-diphenylpropoxy)-7-methoxy-2,4-dimethyl-5-hepten-3-ol

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 24h; Inert atmosphere; Reflux;
DOI:10.1039/c3ob40252e

Reference yield:

: 96013-95-5
3-(tert-butyl-dimethyl-sylanyloxy)benzaldehyde

: 1446347-56-3
(2S,3R,4S,5E,7S)-7-(3-[1-(tert-butyl)-1,1-dimethylsilyl]oxyphenyl)-1-(2,2-dimethyl-1,1-diphenylpropoxy)-7-methoxy-2,4-dimethyl-5-hepten-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2: lipase Amino-I / di-isopropyl ether / 48 h / 20 °C / Inert atmosphere

3: sodium hydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

4: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 24 h / Inert atmosphere; Reflux

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; lipase Amino-I; sodium hydride; In tetrahydrofuran; dichloromethane; di-isopropyl ether;
DOI:10.1039/c3ob40252e

Reference yield:

: 1-(3-((tert-butyldimethylsilyl)oxy)phenyl)prop-2-en-1-ol

: 1446347-56-3
(2S,3R,4S,5E,7S)-7-(3-[1-(tert-butyl)-1,1-dimethylsilyl]oxyphenyl)-1-(2,2-dimethyl-1,1-diphenylpropoxy)-7-methoxy-2,4-dimethyl-5-hepten-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: lipase Amino-I / di-isopropyl ether / 48 h / 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 24 h / Inert atmosphere; Reflux

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; lipase Amino-I; sodium hydride; In tetrahydrofuran; dichloromethane; di-isopropyl ether;
DOI:10.1039/c3ob40252e