4-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazol-3-ylsulfanylmethyl}-benzoic acid methyl ester

Base Information

Chemical Name:4-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazol-3-ylsulfanylmethyl}-benzoic acid methyl ester
CAS No.:146885-26-9
Molecular Formula:C₂₉H₂₉N₇O₂S
Molecular Weight:539.661
Hs Code.:

Synonyms:4-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazol-3-ylsulfanylmethyl}-benzoic acid methyl ester

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Chemical Property of 4-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazol-3-ylsulfanylmethyl}-benzoic acid methyl ester

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Technology Process of 4-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazol-3-ylsulfanylmethyl}-benzoic acid methyl ester

There total 6 articles about 4-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazol-3-ylsulfanylmethyl}-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1026245-86-2
4-[5-Butyl-4-(2'-cyano-biphenyl-4-ylmethyl)-4H-[1,2,4]triazol-3-ylsulfanylmethyl]-benzoic acid methyl ester

: 146885-26-9
4-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazol-3-ylsulfanylmethyl}-benzoic acid methyl ester

Guidance literature:: With trimethyltin azide; In toluene; for 24h; Heating;
DOI:10.1021/jm00057a009

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 146885-26-9
4-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazol-3-ylsulfanylmethyl}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 68 percent / lithium azide / dimethylsulfoxide / 1 h / Ambient temperature

2: triphenylphosphine / 5.5 h / Ambient temperature

3: hydrazine hydrate / tetrahydrofuran / 0.17 h

4: 64 percent / 2-methoxy-ethanol / 4 h / Heating

5: N,N-diisopropylethylamine / 2-methoxy-ethanol / 3.5 h / Ambient temperature

6: 39 percent / trimethyltin azide / toluene / 24 h / Heating

With lithium azide; trimethyltin azide; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 2-methoxy-ethanol; dimethyl sulfoxide; toluene;
DOI:10.1021/jm00057a009

Reference yield:

: 133690-91-2
4'-(azidomethyl)[1,1'-biphenyl]-2-carbonitrile

: 146885-26-9
4-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazol-3-ylsulfanylmethyl}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine / 5.5 h / Ambient temperature

2: hydrazine hydrate / tetrahydrofuran / 0.17 h

3: 64 percent / 2-methoxy-ethanol / 4 h / Heating

4: N,N-diisopropylethylamine / 2-methoxy-ethanol / 3.5 h / Ambient temperature

5: 39 percent / trimethyltin azide / toluene / 24 h / Heating

With trimethyltin azide; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 2-methoxy-ethanol; toluene;
DOI:10.1021/jm00057a009