N-(methylsulfonyl)-4-({4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy}methyl)benzamide diethylamine salt

Base Information

Chemical Name:N-(methylsulfonyl)-4-({4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy}methyl)benzamide diethylamine salt
CAS No.:1355631-31-0
Molecular Formula:C₄H₁₁N*C₂₀H₁₈F₃N₃O₄S
Molecular Weight:526.58
Hs Code.:

Synonyms:N-(methylsulfonyl)-4-({4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy}methyl)benzamide diethylamine salt

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Chemical Property of N-(methylsulfonyl)-4-({4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy}methyl)benzamide diethylamine salt

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Technology Process of N-(methylsulfonyl)-4-({4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy}methyl)benzamide diethylamine salt

There total 6 articles about N-(methylsulfonyl)-4-({4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy}methyl)benzamide diethylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3144-09-0
methanesulfonamide

: C₁₉H₁₅F₃N₂O₃

: 109-89-7
diethylamine

: 1355631-31-0
N-(methylsulfonyl)-4-({4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy}methyl)benzamide diethylamine salt

Guidance literature:: methanesulfonamide; C₁₉H₁₅F₃N₂O₃; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 40 ℃; Inert atmosphere;

diethylamine;

Reference yield:

: 344591-91-9
[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid

: 1355631-31-0
N-(methylsulfonyl)-4-({4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy}methyl)benzamide diethylamine salt

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 4 h / 90 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

3: water; lithium hydroxide / tetrahydrofuran / 6 h / 55 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 40 °C / Inert atmosphere

With dmap; water; potassium carbonate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 154471-65-5
1-methyl-3-trifluoromethylpyrazol

: 1355631-31-0
N-(methylsulfonyl)-4-({4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy}methyl)benzamide diethylamine salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes; hexane / 1 h / -78 °C

1.2: -78 - 20 °C

1.3: 1.5 h / 20 °C

2.1: caesium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 4 h / 90 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 6 h / 55 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 40 °C / Inert atmosphere

With dmap; n-butyllithium; water; potassium carbonate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; hexanes; hexane; dichloromethane; water; N,N-dimethyl-formamide;