tert-butyl(3-iodo-2-{[4-(trifluoromethoxy)phenoxy]methyl}propoxy)dimethylsilane

Base Information

Chemical Name:tert-butyl(3-iodo-2-{[4-(trifluoromethoxy)phenoxy]methyl}propoxy)dimethylsilane
CAS No.:1263188-73-3
Molecular Formula:C₁₇H₂₆F₃IO₃Si
Molecular Weight:490.377
Hs Code.:

Synonyms:tert-butyl(3-iodo-2-{[4-(trifluoromethoxy)phenoxy]methyl}propoxy)dimethylsilane

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Chemical Property of tert-butyl(3-iodo-2-{[4-(trifluoromethoxy)phenoxy]methyl}propoxy)dimethylsilane

Chemical Property:

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Technology Process of tert-butyl(3-iodo-2-{[4-(trifluoromethoxy)phenoxy]methyl}propoxy)dimethylsilane

There total 4 articles about tert-butyl(3-iodo-2-{[4-(trifluoromethoxy)phenoxy]methyl}propoxy)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1263188-72-2
3-[(tert-butyldimethylsilyl)oxy]-2-{[4-(trifluoromethoxy)phenoxy]methyl}propan-1-ol

: 1263188-73-3
tert-butyl(3-iodo-2-{[4-(trifluoromethoxy)phenoxy]methyl}propoxy)dimethylsilane

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 20 ℃; for 15h; Inert atmosphere;

Reference yield:

: 116700-73-3
2-(tert-butyl-dimethyl-silanyloxymethyl)-prop-2-en-1-ol

: 1263188-73-3
tert-butyl(3-iodo-2-{[4-(trifluoromethoxy)phenoxy]methyl}propoxy)dimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 6 h / 5 °C

2.1: potassium carbonate / acetone / 50 °C

3.1: iodine; sodium tetrahydroborate / tetrahydrofuran / 17 h / 0 - 20 °C

3.2: 3 h / 0 - 20 °C

4.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 20 °C

With 1H-imidazole; sodium tetrahydroborate; iodine; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/j.bmcl.2015.07.084

Reference yield:

: 791131-36-7
tert-butyl((2-(iodomethyl)allyl)oxy)dimethylsilane

: 1263188-73-3
tert-butyl(3-iodo-2-{[4-(trifluoromethoxy)phenoxy]methyl}propoxy)dimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 50 °C

2.1: iodine; sodium tetrahydroborate / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 3 h / 0 - 20 °C

3.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 20 °C

With 1H-imidazole; sodium tetrahydroborate; iodine; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/j.bmcl.2015.07.084