4-Fluoro-3-(methoxycarbonyl)phenylboronic acid

Base Information

• Chemical Name: 4-Fluoro-3-(methoxycarbonyl)phenylboronic acid
• CAS No.: 874219-35-9
• Molecular Formula: C8H8BFO4
• Molecular Weight: 197.959
• Hs Code.: 2931900090
• Mol file: 874219-35-9.mol

Synonyms:4-Fluoro-3-methoxycarbonylphenylboronicacid;

Chemical Property of 4-Fluoro-3-(methoxycarbonyl)phenylboronic acid

Chemical Property:

• Appearance/Colour: off-white crystal
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 253-255 °C
• Refractive Index: 1.514
• Boiling Point: 364.767 °C at 760 mmHg
• PKA: 7.82±0.10(Predicted)
• Flash Point: 174.405 °C
• PSA: 66.76000
• Density: 1.339 g/cm³
• LogP: -0.70790
• Storage Temp.: Keep Cold

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoro-3-methoxycarbonylphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39

MSDS Files:

Useful:

• Uses: suzuki reaction

Technology Process of 4-Fluoro-3-(methoxycarbonyl)phenylboronic acid

There total 1 articles about 4-Fluoro-3-(methoxycarbonyl)phenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 2-fluoro-5-iodo-benzoate (625471-27-4) + triethyl borate (150-46-9) → (4-fluoro-3-(methoxycarbonyl)phenyl)boronic acid (874219-35-9)

Guidance literature:

methyl 2-fluoro-5-iodo-benzoate; With TurboGrignard; In tetrahydrofuran; at -40 - -20 ℃; for 1h;

triethyl borate; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

Reference yield: 86.0%

(4-fluoro-3-(methoxycarbonyl)phenyl)boronic acid (874219-35-9) + 4-(bromomethyl)-2H-phthalazin-1-one → methyl 2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoate

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; for 6h;

Reference yield: 85.0%

(4-fluoro-3-(methoxycarbonyl)phenyl)boronic acid (874219-35-9) + (2R)-2-(((tert-butoxycarbonyl)((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-2H-chromen-4-yl trifluoromethanesulfonate (1451373-96-8) → methyl 5-((2R)-2-(((tert-butoxycarbonyl)((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-2H-chromen-4-yl)-2-fluorobenzoate (1451374-16-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 65 ℃; for 1h; Inert atmosphere;

upstream raw materials:

methyl 2-fluoro-5-iodo-benzoate

triethyl borate

Downstream raw materials:

C₃₄H₂₄FN₃O₄

5-[5-(6-amino-pyridin-3-ylethynyl)-6-ethyl-pyrimidin-4-yl]-2-fluoro-benzoic acid methyl ester

C₁₅H₁₄FN₅O₄

benzyl 1-benzyl-6-[4-fluoro-3-(methoxycarbonyl)phenyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

Refernces