2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide

Base Information

Chemical Name:2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide
CAS No.:152038-57-8
Molecular Formula:C₂₂H₂₄N₄OS
Molecular Weight:392.525
Hs Code.:

Synonyms:2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide

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Chemical Property of 2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide

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Technology Process of 2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide

There total 7 articles about 2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 75-04-7,85404-22-4
ethylamine

: 152038-63-6
2-Chloro-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide

: 152038-57-8
2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide

Guidance literature:: In 1,4-dioxane; at 140 ℃; for 5h;
DOI:10.1021/jo00077a016

Reference yield:

: 49609-84-9
2-Chloronicotinoyl chloride

: 152038-57-8
2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / i-Pr₂EtN / ethyl acetate / Ambient temperature

2: 88 percent / KO-t-Bu / dimethylsulfoxide / 0.25 h

3: 94 percent / dioxane / 5 h / 140 °C

With potassium tert-butylate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jo00077a016

Reference yield:

: 38360-81-5
3,5-Dimethylthiophenol

: 152038-57-8
2-(Ethylamino)-N-<4'-<(3'',5''-dimethylphenyl)thio>-3'-pyridinyl>-N-methylpyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / i-Pr₂EtN / dioxane / 2 h / Ambient temperature

2: 94.9 percent / SnCl₂*2H₂O, conc. aq. HCl / acetic acid / 4 h / Ambient temperature

3: 66 percent / i-Pr₂EtN / ethyl acetate / Ambient temperature

4: 88 percent / KO-t-Bu / dimethylsulfoxide / 0.25 h

5: 94 percent / dioxane / 5 h / 140 °C

With hydrogenchloride; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In 1,4-dioxane; acetic acid; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jo00077a016