dimethyl 2-(4-(4-((3-((2-methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonate

Base Information

Chemical Name:dimethyl 2-(4-(4-((3-((2-methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonate
CAS No.:1391622-95-9
Molecular Formula:C₂₇H₃₁N₃O₆S
Molecular Weight:525.626
Hs Code.:

Synonyms:dimethyl 2-(4-(4-((3-((2-methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonate

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Chemical Property of dimethyl 2-(4-(4-((3-((2-methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonate

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Technology Process of dimethyl 2-(4-(4-((3-((2-methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonate

There total 7 articles about dimethyl 2-(4-(4-((3-((2-methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 67-56-1
methanol

: 1370290-34-8
2-(4-(4-((3-((2-methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonic acid

: 1391622-95-9
dimethyl 2-(4-(4-((3-((2-methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonate

Guidance literature:: With sodium; at 22 ℃; for 5h;
DOI:10.1021/jm201734r

Reference yield:

: 177736-20-8
4-(4-formylphenyl)butyric acid ethyl ester

: 1391622-95-9
dimethyl 2-(4-(4-((3-((2-methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; ethanol; water / 16 h / 22 °C

1.2: Sonication

2.1: 1H-imidazole; 1,1'-carbonyldiimidazole / dichloromethane / 3 h / 22 °C

2.2: 16 h / 22 °C

3.1: polymer-supported trisamine resin / toluene / 40 h / 50 - 60 °C / Molecular sieve

3.2: 16 h / 22 °C

3.3: 16 h / 22 °C

4.1: water; sodium hydroxide / ethanol / 16 h / 22 °C

5.1: water / 72 h / 22 °C

6.1: sodium / 5 h / 22 °C

With 1H-imidazole; lithium hydroxide monohydrate; water; sodium; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; 3.1: Knoevenagel condensation;
DOI:10.1021/jm201734r

Reference yield:

: 10031-93-3
ethyl 4-phenylbutyrate

: 1391622-95-9
dimethyl 2-(4-(4-((3-((2-methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid / 16 h / 22 - 80 °C

2.1: lithium hydroxide monohydrate / tetrahydrofuran; ethanol; water / 16 h / 22 °C

2.2: Sonication

3.1: 1H-imidazole; 1,1'-carbonyldiimidazole / dichloromethane / 3 h / 22 °C

3.2: 16 h / 22 °C

4.1: polymer-supported trisamine resin / toluene / 40 h / 50 - 60 °C / Molecular sieve

4.2: 16 h / 22 °C

4.3: 16 h / 22 °C

5.1: water; sodium hydroxide / ethanol / 16 h / 22 °C

6.1: water / 72 h / 22 °C

7.1: sodium / 5 h / 22 °C

With 1H-imidazole; lithium hydroxide monohydrate; water; sodium; 1,1'-carbonyldiimidazole; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; 1.1: Duff reaction / 4.1: Knoevenagel condensation;
DOI:10.1021/jm201734r