2-fluoro-3-hydroxy-3-(4-methoxy-phenyl)-2-phenylselanyl-propionic acid ethyl ester

Base Information

• Chemical Name: 2-fluoro-3-hydroxy-3-(4-methoxy-phenyl)-2-phenylselanyl-propionic acid ethyl ester
• CAS No.: 864363-32-6
• Molecular Formula: C₁₈H₁₉FO₄Se
• Molecular Weight: 397.305
• Mol file: 864363-32-6.mol

Synonyms:2-fluoro-3-hydroxy-3-(4-methoxy-phenyl)-2-phenylselanyl-propionic acid ethyl ester

Chemical Property of 2-fluoro-3-hydroxy-3-(4-methoxy-phenyl)-2-phenylselanyl-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluoro-3-hydroxy-3-(4-methoxy-phenyl)-2-phenylselanyl-propionic acid ethyl ester

There total 2 articles about 2-fluoro-3-hydroxy-3-(4-methoxy-phenyl)-2-phenylselanyl-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-methoxy-benzaldehyde (123-11-5) + α-fluoro-α-(phenylselanyl)acetic acid ethyl ester (142753-36-4) → 2-fluoro-3-hydroxy-3-(4-methoxy-phenyl)-2-phenylselanyl-propionic acid ethyl ester (864363-32-6)

Guidance literature:

α-fluoro-α-(phenylselanyl)acetic acid ethyl ester; With 2,2,6,6-tetramethylpiperidinyl-lithium; at -78 ℃;

4-methoxy-benzaldehyde;

DOI:10.1246/cl.2005.998

Reference yield:

diphenyl diselenide (1666-13-3) → 2-fluoro-3-hydroxy-3-(4-methoxy-phenyl)-2-phenylselanyl-propionic acid ethyl ester (864363-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / NaBH₄ / ethanol

2: 66 percent / lithium 2,2,6,6-tetramethylpiperidide / -78 °C

With sodium tetrahydroborate; 2,2,6,6-tetramethylpiperidinyl-lithium; In ethanol;

DOI:10.1246/cl.2005.998

Reference yield: 75.0%

2-fluoro-3-hydroxy-3-(4-methoxy-phenyl)-2-phenylselanyl-propionic acid ethyl ester (864363-32-6) → diphenyl diselenide (1666-13-3) + (Z)-3-(4-methoxyphenyl)-2-fluoroacrylic acid ethyl ester (26927-88-8)

Guidance literature:

With triethylamine; methyl trifluoromethanesulfonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

DOI:10.1246/cl.2005.998

upstream raw materials:

4-methoxy-benzaldehyde

α-fluoro-α-(phenylselanyl)acetic acid ethyl ester

diphenyl diselenide

Downstream raw materials:

diphenyl diselenide

(Z)-3-(4-methoxyphenyl)-2-fluoroacrylic acid ethyl ester