1-trityl-4-ethoxymethylpyrazole

Base Information

• Chemical Name: 1-trityl-4-ethoxymethylpyrazole
• CAS No.: 1027618-57-0
• Molecular Formula: C₂₅H₂₄N₂O
• Molecular Weight: 368.478
• Mol file: 1027618-57-0.mol

Synonyms:1-trityl-4-ethoxymethylpyrazole

Chemical Property of 1-trityl-4-ethoxymethylpyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1-trityl-4-ethoxymethylpyrazole

There total 4 articles about 1-trityl-4-ethoxymethylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

ethyl iodide (75-03-6) + 4-hydroxymethyl-1-(triphenylmethyl)-pyrazole (88529-69-5) → 1-trityl-4-ethoxymethylpyrazole (1027618-57-0)

Guidance literature:

4-hydroxymethyl-1-(triphenylmethyl)-pyrazole; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 4h;

ethyl iodide; In tetrahydrofuran; mineral oil; for 2h;

DOI:10.1016/j.jorganchem.2013.11.013

Reference yield: 87.0%

→ 1-trityl-4-ethoxymethylpyrazole (1027618-57-0)

Guidance literature:

Reference yield:

trityl chloride (76-83-5) → 1-trityl-4-ethoxymethylpyrazole (1027618-57-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 20 °C

3.1: sodium hydride / mineral oil; tetrahydrofuran / 4 h / 20 °C

3.2: 2 h

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.jorganchem.2013.11.013

upstream raw materials:

ethyl 1-(triphenylmethyl)-pyrazole-4-carboxylate

trityl chloride

ethyl iodide

4-hydroxymethyl-1-(triphenylmethyl)-pyrazole