5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine
CAS No.:875302-41-3
Molecular Formula:C₃₇H₄₆N₂O₈Si
Molecular Weight:674.866
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine

Suppliers and Price of 5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine

There total 3 articles about 5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 875302-39-9
5'-O-(4,4'-dimethoxitrityl)-1-N-methylpseudouridine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 875302-43-5
5'-O-(4,4'-dimethoxitrityl)-3'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine

: 875302-41-3
5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine

Guidance literature:: 5'-O-(4,4'-dimethoxitrityl)-1-N-methylpseudouridine; With pyridine; silver nitrate; In tetrahydrofuran; at 20 ℃; for 0.333333h; Inert atmosphere;

4,4'-dimethoxytrityl chloride; With tert-butyldimethylsilyl chloride; In tetrahydrofuran; at 20 ℃; for 3 - 4h; Inert atmosphere;

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 875302-41-3
5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2-(Dimethylamino)pyridine / pyridine / 20 °C / Inert atmosphere

2.1: pyridine; silver nitrate / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

2.2: 3 - 4 h / 20 °C / Inert atmosphere

With pyridine; 2-(Dimethylamino)pyridine; silver nitrate; In tetrahydrofuran; pyridine;

Reference yield:

: 13860-38-3
N¹-methylpseudouridine

: 875302-41-3
5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2-(Dimethylamino)pyridine / pyridine / 20 °C / Inert atmosphere

2.1: pyridine; silver nitrate / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

2.2: 3 - 4 h / 20 °C / Inert atmosphere

With pyridine; 2-(Dimethylamino)pyridine; silver nitrate; In tetrahydrofuran; pyridine;