Welcome to LookChem.com Sign In|Join Free

CAS

  • or

13860-38-3

Post Buying Request

13860-38-3 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • China Largest factory Manufacturer Supply High Quality 1-methylpseudouridine CAS 13860-38-3

    Cas No: 13860-38-3

  • USD $ 1.0-3.0 / Kilogram

  • 1 Kilogram

  • 1000 Kilogram/Day

  • Leader Biochemical Group
  • Contact Supplier

13860-38-3 Usage

Description

1-Methylpseudouridine is a modified nucleoside that plays a crucial role in enhancing mRNA translation. It is characterized by the presence of a methyl group at the N-1 position on the uracil ring, which distinguishes it from other modified nucleosides. The incorporation of 1-methylpseudouridine into mRNA leads to the suppression of immune/eIF2α phosphorylation-dependent inhibition of translation, resulting in increased ribosome pausing and density on the mRNA. This, in turn, significantly facilitates the translation process, making it a superior choice compared to other modified nucleosides such as 5-Methylcytidine.

Uses

Used in Biotechnology and Pharmaceutical Industry:
1-Methylpseudouridine is used as a substitute for uridine in modified mRNA for various applications in the biotechnology and pharmaceutical industries. The substitution of uridine with 1-methylpseudouridine in mRNA has been shown to increase transfection efficiency by reducing immunogenicity. This is achieved by the modified mRNA's ability to evade detection by the edosomal Toll-like receptor (TLR3), which leads to lower immune stimulation and consequently, enhanced protein expression.

References

1. Svitkin YV, Cheng YM, Chakraborty T, et al. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density. Nucleic Acids Research, 2017, 45(10): 6023-6036.2. Andries O, Mc Cafferty S, De Smedt SC, et al N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice. Journal of Controlled Release, 2015, 217: 337-344.

Check Digit Verification of cas no

The CAS Registry Mumber 13860-38-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,8,6 and 0 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 13860-38:
(7*1)+(6*3)+(5*8)+(4*6)+(3*0)+(2*3)+(1*8)=103
103 % 10 = 3
So 13860-38-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2O6/c1-12-2-4(9(16)11-10(12)17)8-7(15)6(14)5(3-13)18-8/h2,5-8,13-15H,3H2,1H3,(H,11,16,17)

13860-38-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-methylpseudouridine

1.2 Other means of identification

Product number -
Other names 1-Methylpseudouridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13860-38-3 SDS

13860-38-3Relevant articles and documents

Nucleosides. CVI. Synthesis of 1 N methyl 5 (β D ribofuranosyl)uracil (1 N methyl psi uridine) and its identity with a metabolite elaborated by Streptomyces platensis var. clarensis

Reichman,Hirota,Chu,et al.

, p. 129 - 131 (1977)

-

Synthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives

Chang, Yu-Cheng,Herath, Jayatilake,Wang, Tony H.-H.,Chow, Christine S.

, p. 2676 - 2686 (2008/09/21)

A series of 3-substituted uridine and pseudouridine derivatives, based on the naturally occurring 3-(3-amino-3-carboxypropyl) modification, were synthesized. Their aqueous solution conformations were determined by using circular dichroism and NMR spectroscopy. Functional group composition and chain length were shown to have only a subtle influence on the distribution of syn/anti conformations of the modified nucleosides. The dominating factor appears to be the glycosidic linkage (C- vs. N-glycoside) in determining the nucleoside conformation.

Nucleosides. 120. Syntheses of 2'-deoxy-ψ-isocytidine and 2'-deoxy-1-methyl-ψ-uridine from ψ-uridine

Matsuda,Chu,Reichman,et al.

, p. 3603 - 3609 (2007/10/02)

-

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 13860-38-3