5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-methylpseudouridine 3'-O-caynoethyl-N,N-diisopropylphosphoramidate

Base Information

Chemical Name:5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-methylpseudouridine 3'-O-caynoethyl-N,N-diisopropylphosphoramidate
CAS No.:875302-45-7
Molecular Formula:C₄₆H₆₃N₄O₉PSi
Molecular Weight:875.087
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-methylpseudouridine 3'-O-caynoethyl-N,N-diisopropylphosphoramidate

Suppliers and Price of 5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-methylpseudouridine 3'-O-caynoethyl-N,N-diisopropylphosphoramidate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 7 raw suppliers

Chemical Property of 5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-methylpseudouridine 3'-O-caynoethyl-N,N-diisopropylphosphoramidate

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of 5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-methylpseudouridine 3'-O-caynoethyl-N,N-diisopropylphosphoramidate

There total 4 articles about 5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-methylpseudouridine 3'-O-caynoethyl-N,N-diisopropylphosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 875302-41-3
5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 875302-45-7
5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-methylpseudouridine 3'-O-caynoethyl-N,N-diisopropylphosphoramidate

Guidance literature:: With 2-(Dimethylamino)pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4 - 6h; Inert atmosphere;

Reference yield:

: 875302-39-9
5'-O-(4,4'-dimethoxitrityl)-1-N-methylpseudouridine

: 875302-45-7
5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-methylpseudouridine 3'-O-caynoethyl-N,N-diisopropylphosphoramidate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; silver nitrate / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

1.2: 3 - 4 h / 20 °C / Inert atmosphere

2.1: 2-(Dimethylamino)pyridine; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 - 6 h / 20 °C / Inert atmosphere

With pyridine; 2-(Dimethylamino)pyridine; silver nitrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 875302-45-7
5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-methylpseudouridine 3'-O-caynoethyl-N,N-diisopropylphosphoramidate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2-(Dimethylamino)pyridine / pyridine / 20 °C / Inert atmosphere

2.1: pyridine; silver nitrate / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

2.2: 3 - 4 h / 20 °C / Inert atmosphere

3.1: 2-(Dimethylamino)pyridine; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 - 6 h / 20 °C / Inert atmosphere

With pyridine; 2-(Dimethylamino)pyridine; silver nitrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; dichloromethane;