Technology Process of (3S,5S)-5-Isopropenyl-3-(4-methoxy-2,6-dimethyl-benzyl)-2,2,6-trimethyl-cyclohexanone
There total 8 articles about (3S,5S)-5-Isopropenyl-3-(4-methoxy-2,6-dimethyl-benzyl)-2,2,6-trimethyl-cyclohexanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 24h;
DOI:10.1055/s-2002-34902
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 73 percent / PPh3; CBr4 / Pd2(dba)3 / CH2Cl2 / 0.5 h / 0 - 20 °C
2.1: Li / tetrahydrofuran / 1 h
3.1: PCC; silica gel / CH2Cl2 / 6 h
4.1: Li; NH3 / tetrahydrofuran / 0.25 h
4.2: 45 percent / tetrahydrofuran / 1 h
5.1: 70 percent / LDA; HMPA / tetrahydrofuran / 24 h / 0 - 20 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; carbon tetrabromide; ammonia; silica gel; lithium; triphenylphosphine; pyridinium chlorochromate; lithium diisopropyl amide;
tris(dibenzylideneacetone)dipalladium (0);
In
tetrahydrofuran; dichloromethane;
2.1: Barbier reaction;
DOI:10.1055/s-2002-34902
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 82 percent / Br2 / CH2Cl2 / 0.25 h / 0 °C
2.1: Li / tetrahydrofuran / 1 h
3.1: NaBH4 / methanol / 0 °C
4.1: 73 percent / PPh3; CBr4 / Pd2(dba)3 / CH2Cl2 / 0.5 h / 0 - 20 °C
5.1: Li / tetrahydrofuran / 1 h
6.1: PCC; silica gel / CH2Cl2 / 6 h
7.1: Li; NH3 / tetrahydrofuran / 0.25 h
7.2: 45 percent / tetrahydrofuran / 1 h
8.1: 70 percent / LDA; HMPA / tetrahydrofuran / 24 h / 0 - 20 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; carbon tetrabromide; ammonia; bromine; silica gel; lithium; triphenylphosphine; pyridinium chlorochromate; lithium diisopropyl amide;
tris(dibenzylideneacetone)dipalladium (0);
In
tetrahydrofuran; methanol; dichloromethane;
5.1: Barbier reaction;
DOI:10.1055/s-2002-34902
