C₄₄H₄₇F₃O₉Si

Base Information

• Chemical Name: C₄₄H₄₇F₃O₉Si
• CAS No.: 1315504-10-9
• Molecular Formula: C₄₄H₄₇F₃O₉Si
• Molecular Weight: 804.932
• Mol file: 1315504-10-9.mol

Synonyms:C₄₄H₄₇F₃O₉Si

Chemical Property of C₄₄H₄₇F₃O₉Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₄H₄₇F₃O₉Si

There total 23 articles about C₄₄H₄₇F₃O₉Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C34H40O7Si (1315503-85-5) + (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) → C44H47F3O9Si (1315504-10-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/ja205339p

Reference yield:

1-(bromomethyl)-3-{[(tert-butyl)(dimethyl)sily]oxy}-5-methylbenzene (1308657-93-3) → C44H47F3O9Si (1315504-10-9)

Guidance literature:

Multi-step reaction with 10 steps

1.1: water; dimethyl sulfoxide / 20 °C

2.1: potassium hydroxide / ethanol; water / 5 h / Reflux

3.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h

4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 5 h / 20 °C

5.1: pyridine / dichloromethane / 0.5 h / 20 °C

6.1: tetrahydrofuran / 0.5 h / -20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.67 h / -78 °C

7.2: 0.08 h / 0 °C

8.1: borane-THF; (S)-Corey-Bakshi-Shibata oxazaborolidine / tetrahydrofuran; toluene / 2.5 h / -20 °C

9.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0 °C

10.1: dmap; triethylamine / dichloromethane / 2 h / 0 °C

With pyridine; 1H-imidazole; dmap; ammonium cerium (IV) nitrate; borane-THF; oxalyl dichloride; triethylamine; potassium hydroxide; lithium hexamethyldisilazane; (S)-Corey-Bakshi-Shibata oxazaborolidine; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1021/ja205339p

Reference yield:

C22H25NO4Si → C44H47F3O9Si (1315504-10-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.67 h / -78 °C

3.2: 0.08 h / 0 °C

4.1: borane-THF; (S)-Corey-Bakshi-Shibata oxazaborolidine / tetrahydrofuran; toluene / 2.5 h / -20 °C

5.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0 °C

6.1: dmap; triethylamine / dichloromethane / 2 h / 0 °C

With dmap; ammonium cerium (IV) nitrate; borane-THF; tetrabutyl ammonium fluoride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; (S)-Corey-Bakshi-Shibata oxazaborolidine; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;

DOI:10.1021/ja205339p

upstream raw materials:

1-(bromomethyl)-3-{[(tert-butyl)(dimethyl)sily]oxy}-5-methylbenzene

7-(benzyloxy)-4-hydroxy-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

7-(benzyloxy)-4-(methoxymethoxy)-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile

2-(3-(tert-butyldimethylsilyloxy)-5-methylphenyl)acetonitrile