β-chloro-β-phenylalanine methyl ester hydrochloride

Base Information

• Chemical Name: β-chloro-β-phenylalanine methyl ester hydrochloride
• CAS No.: 100020-81-3
• Molecular Formula: C₁₀H₁₂ClNO₂*ClH
• Molecular Weight: 250.125
• Mol file: 100020-81-3.mol

Synonyms:β-chloro-β-phenylalanine methyl ester hydrochloride

Chemical Property of β-chloro-β-phenylalanine methyl ester hydrochloride

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of β-chloro-β-phenylalanine methyl ester hydrochloride

There total 5 articles about β-chloro-β-phenylalanine methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

β-hydroxyphenylalanine methyl ester hydrochloride (80182-99-6) → β-chloro-β-phenylalanine methyl ester hydrochloride (100020-81-3)

Guidance literature:

With thionyl chloride; In chloroform; for 12h; Ambient temperature;

DOI:10.1021/jo00357a036

Reference yield:

benzaldehyde (100-52-7) → β-chloro-β-phenylalanine methyl ester hydrochloride (100020-81-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 74.8 percent / NaOH / methanol; H₂O / 1.) 16 dg C, 30 min; 2.) RT, overnight

2: SOCl₂ / 4 h

3: SOCl₂ / 10 h / Heating

With sodium hydroxide; thionyl chloride; In methanol; water;

Reference yield:

→ β-chloro-β-phenylalanine methyl ester hydrochloride (100020-81-3)

Guidance literature:

With phosphorus pentachloride; acetyl chloride;

upstream raw materials:

methanol

β-chloro-β-phenylalanine

β-hydroxyphenylalanine methyl ester hydrochloride

Phenylserin

Downstream raw materials:

methyl 2-amino-3-phenylpropanoate hydrochloride

N-(N-formyl-α-L-aspartyl)-D,L-2-chlorophenylalanine methyl ester

Refernces

• 1、 Fuganti, Claudio,Grasselli, Piero,Malpezzi, Luciana. "Synthesis of Aspartame via Asymmetric Hydrogenation of N-Protected (Z)-N-α-L-Aspartyl-Δ-phenylalanine Methyl Ester". . p. 1126 - 1128. Retrieved 2007/10/02.