3-(4-tert-butoxycarbonyl-piperazine-1-carbonyl)-2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-7-carboxylic acid methyl ester

Base Information

Chemical Name:3-(4-tert-butoxycarbonyl-piperazine-1-carbonyl)-2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-7-carboxylic acid methyl ester
CAS No.:1262891-87-1
Molecular Formula:C₃₄H₃₆FN₃O₅
Molecular Weight:585.675
Hs Code.:

Synonyms:3-(4-tert-butoxycarbonyl-piperazine-1-carbonyl)-2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-7-carboxylic acid methyl ester

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Chemical Property of 3-(4-tert-butoxycarbonyl-piperazine-1-carbonyl)-2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-7-carboxylic acid methyl ester

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Technology Process of 3-(4-tert-butoxycarbonyl-piperazine-1-carbonyl)-2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-7-carboxylic acid methyl ester

There total 11 articles about 3-(4-tert-butoxycarbonyl-piperazine-1-carbonyl)-2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-7-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262891-86-0
2-(3-fluoro-2-methyl-benzyl)-7-methoxycarbonyl-1-phenyl-indolizine-3-carboxylic acid

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1262891-87-1
3-(4-tert-butoxycarbonyl-piperazine-1-carbonyl)-2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-7-carboxylic acid methyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 58481-11-1
methyl 2-chloroisonicotinate

: 1262891-87-1
3-(4-tert-butoxycarbonyl-piperazine-1-carbonyl)-2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-7-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / palladium diacetate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

2.1: acetone / Reflux

2.2: 2 h / 105 °C

3.1: trichlorophosphate / 0 - 60 °C / Inert atmosphere

3.2: 1 h / 50 °C

4.1: water; sodium chlorite; sodium dihydrogenphosphate / 2-methyl-but-2-ene; tert-butyl alcohol; tetrahydrofuran / 0 - 20 °C

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0 - 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trichlorophosphate; palladium diacetate; In tetrahydrofuran; 2-methyl-but-2-ene; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;

Reference yield:

: 53317-09-2
9-benzyl-9-borabicyclo[3.3.1]nonane

: 1262891-87-1
3-(4-tert-butoxycarbonyl-piperazine-1-carbonyl)-2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-7-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / palladium diacetate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

2.1: acetone / Reflux

2.2: 2 h / 105 °C

3.1: trichlorophosphate / 0 - 60 °C / Inert atmosphere

3.2: 1 h / 50 °C

4.1: water; sodium chlorite; sodium dihydrogenphosphate / 2-methyl-but-2-ene; tert-butyl alcohol; tetrahydrofuran / 0 - 20 °C

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0 - 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trichlorophosphate; palladium diacetate; In tetrahydrofuran; 2-methyl-but-2-ene; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;