4-[2-(3-fluoro-2-methyl-benzyl)-7-methylcarbamoyl-1-phenyl-indolizine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-[2-(3-fluoro-2-methyl-benzyl)-7-methylcarbamoyl-1-phenyl-indolizine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:1262891-89-3
Molecular Formula:C₃₄H₃₇FN₄O₄
Molecular Weight:584.691
Hs Code.:

Synonyms:4-[2-(3-fluoro-2-methyl-benzyl)-7-methylcarbamoyl-1-phenyl-indolizine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-[2-(3-fluoro-2-methyl-benzyl)-7-methylcarbamoyl-1-phenyl-indolizine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-[2-(3-fluoro-2-methyl-benzyl)-7-methylcarbamoyl-1-phenyl-indolizine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

There total 13 articles about 4-[2-(3-fluoro-2-methyl-benzyl)-7-methylcarbamoyl-1-phenyl-indolizine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262891-88-2
3-(4-tert-butoxycarbonyl-piperazine-1-carbonyl)-2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-7-carboxylic acid

: 593-51-1
methylamine hydrochloride

: 1262891-89-3
4-[2-(3-fluoro-2-methyl-benzyl)-7-methylcarbamoyl-1-phenyl-indolizine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; at 0 - 20 ℃;

Reference yield:

: 58481-11-1
methyl 2-chloroisonicotinate

: 1262891-89-3
4-[2-(3-fluoro-2-methyl-benzyl)-7-methylcarbamoyl-1-phenyl-indolizine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / palladium diacetate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

2.1: acetone / Reflux

2.2: 2 h / 105 °C

3.1: trichlorophosphate / 0 - 60 °C / Inert atmosphere

3.2: 1 h / 50 °C

4.1: water; sodium chlorite; sodium dihydrogenphosphate / 2-methyl-but-2-ene; tert-butyl alcohol; tetrahydrofuran / 0 - 20 °C

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0 - 20 °C

6.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 50 °C

6.2: pH 1

7.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 0 - 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; lithium hydroxide monohydrate; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trichlorophosphate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; 2-methyl-but-2-ene; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;

Reference yield:

: 53317-09-2
9-benzyl-9-borabicyclo[3.3.1]nonane

: 1262891-89-3
4-[2-(3-fluoro-2-methyl-benzyl)-7-methylcarbamoyl-1-phenyl-indolizine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / palladium diacetate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

2.1: acetone / Reflux

2.2: 2 h / 105 °C

3.1: trichlorophosphate / 0 - 60 °C / Inert atmosphere

3.2: 1 h / 50 °C

4.1: water; sodium chlorite; sodium dihydrogenphosphate / 2-methyl-but-2-ene; tert-butyl alcohol; tetrahydrofuran / 0 - 20 °C

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0 - 20 °C

6.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 50 °C

6.2: pH 1

7.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 0 - 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; lithium hydroxide monohydrate; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trichlorophosphate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; 2-methyl-but-2-ene; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;