2-nitrophenoxyacetyl-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyryl)-L-proline tert butyl amide

Base Information

Chemical Name:2-nitrophenoxyacetyl-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyryl)-L-proline tert butyl amide
CAS No.:209258-72-0
Molecular Formula:C₂₇H₃₄N₄O₇
Molecular Weight:526.59
Hs Code.:

Synonyms:2-nitrophenoxyacetyl-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyryl)-L-proline tert butyl amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-nitrophenoxyacetyl-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyryl)-L-proline tert butyl amide

Chemical Property:

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Technology Process of 2-nitrophenoxyacetyl-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyryl)-L-proline tert butyl amide

There total 4 articles about 2-nitrophenoxyacetyl-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyryl)-L-proline tert butyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128018-17-7
Z-Pro-NH^tBu

: 209258-72-0
2-nitrophenoxyacetyl-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyryl)-L-proline tert butyl amide

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / methanol / 10 h

2: WSC*HCl, HOBt*H₂O, DMAP, TEA / dimethylformamide / 8 h / Ambient temperature

3: H₂ / Pd/C / methanol / 10 h

4: WSC*HCl, HOBt*H₂O, DMAP, TEA / dimethylformamide / 4 h / Ambient temperature

With dmap; WSC*HCl; TEA; hydrogen; benzotriazol-1-ol; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.867

Reference yield:

: 128018-18-8
L-proline tert-butylamide

: 209258-72-0
2-nitrophenoxyacetyl-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyryl)-L-proline tert butyl amide

Guidance literature:: Multi-step reaction with 3 steps

1: WSC*HCl, HOBt*H₂O, DMAP, TEA / dimethylformamide / 8 h / Ambient temperature

2: H₂ / Pd/C / methanol / 10 h

3: WSC*HCl, HOBt*H₂O, DMAP, TEA / dimethylformamide / 4 h / Ambient temperature

With dmap; WSC*HCl; TEA; hydrogen; benzotriazol-1-ol; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.867

Reference yield:

: 141171-72-4
(2S,3S)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutyryl-L-prolyl-tert-butyl amide

: 209258-72-0
2-nitrophenoxyacetyl-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyryl)-L-proline tert butyl amide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 10 h

2: WSC*HCl, HOBt*H₂O, DMAP, TEA / dimethylformamide / 4 h / Ambient temperature

With dmap; WSC*HCl; TEA; hydrogen; benzotriazol-1-ol; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.867