4-[4-chloro-2-(2-chloro-4-nitro-phenylcarbamoyl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-[4-chloro-2-(2-chloro-4-nitro-phenylcarbamoyl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1420290-93-2
• Molecular Formula: C₂₃H₂₅Cl₂N₃O₆
• Molecular Weight: 510.374

Synonyms:4-[4-chloro-2-(2-chloro-4-nitro-phenylcarbamoyl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-[4-chloro-2-(2-chloro-4-nitro-phenylcarbamoyl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

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Technology Process of 4-[4-chloro-2-(2-chloro-4-nitro-phenylcarbamoyl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester

There total 1 articles about 4-[4-chloro-2-(2-chloro-4-nitro-phenylcarbamoyl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

Niclosamide (50-65-7) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 4-[4-chloro-2-(2-chloro-4-nitro-phenylcarbamoyl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester (1420290-93-2)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ml3003082

Reference yield: 58.0%

4-[4-chloro-2-(2-chloro-4-nitro-phenylcarbamoyl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester (1420290-93-2) → 5-chloro-N-(2-chloro-4-nitro-phenyl)-2-(piperidin-4-yloxy)benzamide (1420290-87-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

4-[4-chloro-2-(2-chloro-4-nitro-phenylcarbamoyl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester (1420290-93-2) → C23H27Cl2N3O4 (1420290-94-3)

Guidance literature:

With methanol; ammonium chloride; zinc; In water; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ml3003082

upstream raw materials:

Niclosamide

t-butyl 4-hydroxy piperidine-1-carboxylate

Downstream raw materials:

5-chloro-N-(2-chloro-4-nitro-phenyl)-2-(piperidin-4-yloxy)benzamide

C₂₃H₂₇Cl₂N₃O₄

C₁₉H₂₁Cl₂N₃O₄S

N-(4-acetylamino-2-chloro-phenyl)-5-chloro-2-(piperidin-4-yloxy)benzamide

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