N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methyl-3-[methyI(oxan-4-yl)amino]-5-(1-methyIazetidin-3-yl)benzamide

Base Information

Chemical Name:N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methyl-3-[methyI(oxan-4-yl)amino]-5-(1-methyIazetidin-3-yl)benzamide
CAS No.:1403591-08-1
Molecular Formula:C₂₆H₃₆N₄O₃
Molecular Weight:452.597
Hs Code.:

Synonyms:N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methyl-3-[methyI(oxan-4-yl)amino]-5-(1-methyIazetidin-3-yl)benzamide

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Chemical Property of N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methyl-3-[methyI(oxan-4-yl)amino]-5-(1-methyIazetidin-3-yl)benzamide

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Technology Process of N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methyl-3-[methyI(oxan-4-yl)amino]-5-(1-methyIazetidin-3-yl)benzamide

There total 10 articles about N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methyl-3-[methyI(oxan-4-yl)amino]-5-(1-methyIazetidin-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 771579-27-2
3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one

: 1403597-89-6
2-methyl-3-[methyl(oxan-4-yl)amino]-5-(1-methylazetidin-3-yl)benzoic acid

: 1403591-08-1
N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methyl-3-[methyI(oxan-4-yl)amino]-5-(1-methyIazetidin-3-yl)benzamide

Guidance literature:: 2-methyl-3-[methyl(oxan-4-yl)amino]-5-(1-methylazetidin-3-yl)benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1403591-08-1
N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methyl-3-[methyI(oxan-4-yl)amino]-5-(1-methyIazetidin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

3.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

3.2: 64 h

4.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

4.2: 34 h / 20 °C

4.3: pH 7

5.1: chloro-trimethyl-silane; zinc; ethylene dibromide / ISOPROPYLAMIDE / 90 h / 80 °C / Inert atmosphere

5.2: 1.5 h / 80 °C

6.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

6.2: pH 7 - 8

7.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

7.2: 20 h / 20 °C

7.3: pH 7

8.1: sodium hydroxide / tetrahydrofuran; methanol / 40 h / 50 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 0 °C

9.2: 16 h / 0 - 20 °C

With chloro-trimethyl-silane; iron; sodium carbonate; ammonium chloride; acetic acid; ethylene dibromide; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium hydroxide; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 220514-28-3
5-bromo-2-methyl-3-nitrobenzoic acid methyl ester

: 1403591-08-1
N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methyl-3-[methyI(oxan-4-yl)amino]-5-(1-methyIazetidin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

2.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

2.2: 64 h

3.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

3.2: 34 h / 20 °C

3.3: pH 7

4.1: chloro-trimethyl-silane; zinc; ethylene dibromide / ISOPROPYLAMIDE / 90 h / 80 °C / Inert atmosphere

4.2: 1.5 h / 80 °C

5.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

5.2: pH 7 - 8

6.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

6.2: 20 h / 20 °C

6.3: pH 7

7.1: sodium hydroxide / tetrahydrofuran; methanol / 40 h / 50 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 0 °C

8.2: 16 h / 0 - 20 °C

With chloro-trimethyl-silane; iron; ammonium chloride; acetic acid; ethylene dibromide; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium hydroxide; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;