(R(S))-N-(R)-[1-(2-aminophenyl)ethyl]-N,2-dimethyl-2-propanesulfinamide

Base Information

• Chemical Name: (R(S))-N-(R)-[1-(2-aminophenyl)ethyl]-N,2-dimethyl-2-propanesulfinamide
• CAS No.: 1287718-54-0
• Molecular Formula: C₁₃H₂₂N₂OS
• Molecular Weight: 254.396
• Mol file: 1287718-54-0.mol

Synonyms:(R(S))-N-(R)-[1-(2-aminophenyl)ethyl]-N,2-dimethyl-2-propanesulfinamide

Chemical Property of (R(S))-N-(R)-[1-(2-aminophenyl)ethyl]-N,2-dimethyl-2-propanesulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R(S))-N-(R)-[1-(2-aminophenyl)ethyl]-N,2-dimethyl-2-propanesulfinamide

There total 3 articles about (R(S))-N-(R)-[1-(2-aminophenyl)ethyl]-N,2-dimethyl-2-propanesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(R(S))-N-(R)-[1-(2-aminophenyl)ethyl]-2-methyl-2-propanesulfinamide + methyl iodide (74-88-4) → (R(S))-N-(R)-[1-(2-aminophenyl)ethyl]-N,2-dimethyl-2-propanesulfinamide (1287718-54-0)

Guidance literature:

(R(S))-N-(R)-[1-(2-aminophenyl)ethyl]-2-methyl-2-propanesulfinamide; With lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at -20 ℃; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; N,N-dimethyl-formamide; for 2h; Inert atmosphere;

DOI:10.1021/jo1025767

Reference yield:

N-[(E)-1-(2-aminophenyl)ethylidene]-2-methyl-(R(S))-2-propanesulfinamide (1287718-14-2) → (R(S))-N-(R)-[1-(2-aminophenyl)ethyl]-N,2-dimethyl-2-propanesulfinamide (1287718-54-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 3 h / -78 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / -20 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere

With diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1021/jo1025767

Reference yield:

2-aminoacetophenone (551-93-9) → (R(S))-N-(R)-[1-(2-aminophenyl)ethyl]-N,2-dimethyl-2-propanesulfinamide (1287718-54-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: titanium(IV) tetraethanolate / 12 h / 75 °C / Inert atmosphere

1.2: 0.17 h

2.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 3 h / -78 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / -20 °C / Inert atmosphere

3.2: 2 h / Inert atmosphere

With titanium(IV) tetraethanolate; diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1021/jo1025767

upstream raw materials:

N-[(E)-1-(2-aminophenyl)ethylidene]-2-methyl-(R(S))-2-propanesulfinamide

methyl iodide

2-aminoacetophenone

Downstream raw materials:

(1R)-1-(2-aminophenyl)-N-methyl-1-ethanamine