(Z)-3-tert-Butylamino-2-(2,4-dichloro-5-nitro-benzoyl)-acrylic acid ethyl ester

Base Information

• Chemical Name: (Z)-3-tert-Butylamino-2-(2,4-dichloro-5-nitro-benzoyl)-acrylic acid ethyl ester
• CAS No.: 161040-31-9
• Molecular Formula: C₁₆H₁₈Cl₂N₂O₅
• Molecular Weight: 389.235

Synonyms:(Z)-3-tert-Butylamino-2-(2,4-dichloro-5-nitro-benzoyl)-acrylic acid ethyl ester

Chemical Property of (Z)-3-tert-Butylamino-2-(2,4-dichloro-5-nitro-benzoyl)-acrylic acid ethyl ester

Chemical Property:

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Technology Process of (Z)-3-tert-Butylamino-2-(2,4-dichloro-5-nitro-benzoyl)-acrylic acid ethyl ester

There total 5 articles about (Z)-3-tert-Butylamino-2-(2,4-dichloro-5-nitro-benzoyl)-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butylamine (75-64-9) + ethyl ester of 3-dimethylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid (148926-94-7) → (Z)-3-tert-Butylamino-2-(2,4-dichloro-5-nitro-benzoyl)-acrylic acid ethyl ester (161040-31-9)

Guidance literature:

In diethyl ether; ethanol; for 0.25h; Ambient temperature;

DOI:10.1021/jm00006a017

Reference yield:

ethyl 3-(dimethylamino)acrylate (924-99-2,1117-37-9,114894-59-6) → (Z)-3-tert-Butylamino-2-(2,4-dichloro-5-nitro-benzoyl)-acrylic acid ethyl ester (161040-31-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / toluene / 1 h / 90 °C

2: 96 percent / ethanol; diethyl ether / 0.25 h / Ambient temperature

With triethylamine; In diethyl ether; ethanol; toluene;

DOI:10.1021/jm00006a017

Reference yield:

2,4-dichloro-5-nitro benzoyl chloride (713-28-0) → (Z)-3-tert-Butylamino-2-(2,4-dichloro-5-nitro-benzoyl)-acrylic acid ethyl ester (161040-31-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / toluene / 1 h / 90 °C

2: 96 percent / ethanol; diethyl ether / 0.25 h / Ambient temperature

With triethylamine; In diethyl ether; ethanol; toluene;

DOI:10.1021/jm00006a017

upstream raw materials:

tert-butylamine

ethyl ester of 3-dimethylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid

ethyl 3-(dimethylamino)acrylate

2,4-dichloro-5-nitro benzoyl chloride

Downstream raw materials:

6-Amino-1-tert-butyl-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

6-Amino-1-tert-butyl-4-oxo-7-pyrrolidin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

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