3-(Dimethylamino)-1-(thiophen-3-yl)propan-1-ol

Base Information

Chemical Name:3-(Dimethylamino)-1-(thiophen-3-yl)propan-1-ol
CAS No.:116817-84-6
Molecular Formula:C9H15NOS
Molecular Weight:185.29
Hs Code.:2934999090
European Community (EC) Number:601-450-6
DSSTox Substance ID:DTXSID701248385
Mol file:116817-84-6.mol

Synonyms:116817-84-6;3-(dimethylamino)-1-(thiophen-3-yl)propan-1-ol;rac-alpha-[2-(Dimethylamino)ethyl]-3-thiophenemethanol;3-(dimethylamino)-1-thiophen-3-ylpropan-1-ol;Duloxetine IMpurity 18;(S)-3-(Dimethylamino)-1-(thiophen-3-yl)propan-1-ol;SCHEMBL3461;DTXSID701248385;AKOS006291528;SB47713;CS-0441433;S-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)-1-propylamide

Suppliers and Price of 3-(Dimethylamino)-1-(thiophen-3-yl)propan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
rac-α-[2-(Dimethylamino)ethyl]-3-thiophenemethanol
500mg
$ 1040.00

Biosynth Carbosynth
3-(Dimethylamino)-1-(3-thienyl)propan-1-ol
100 mg
$ 200.00

Biosynth Carbosynth
3-(Dimethylamino)-1-(3-thienyl)propan-1-ol
50 mg
$ 125.00

Biosynth Carbosynth
3-(Dimethylamino)-1-(3-thienyl)propan-1-ol
25 mg
$ 87.50

Biosynth Carbosynth
3-(Dimethylamino)-1-(3-thienyl)propan-1-ol
10 mg
$ 50.00

American Custom Chemicals Corporation
3-(DIMETHYLAMINO)-1-(THIOPHEN-3-YL)PROPAN-1-OL 95.00%
5MG
$ 496.50

Total 62 raw suppliers

Chemical Property of 3-(Dimethylamino)-1-(thiophen-3-yl)propan-1-ol

Chemical Property:

Melting Point:74-76°C
Boiling Point:290.1±30.0 °C(Predicted)
PKA:14.35±0.20(Predicted)
PSA：51.71000
Density:1.111±0.06 g/cm3(Predicted)
LogP:1.73320
Storage Temp.:Room Temperature, under inert atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:185.08743528
Heavy Atom Count:12
Complexity:130

Purity/Quality:

97% ^*data from raw suppliers

rac-α-[2-(Dimethylamino)ethyl]-3-thiophenemethanol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)CCC(C1=CSC=C1)O
Uses S-(+)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)-1-propylamide is a useful synthetic intermediate. rac-α-[2-(Dimethylamino)ethyl]-3-thiophenemethanol is an intermediate in the synthesis of rac Duloxetine 3-Thiophene Isomer (D721025). rac Duloxetine 3-Thiophene Isomer Hydrochloride is an isomeric impurity of the antidepressant Duloxetine Hydrochloride (D721000).

Technology Process of 3-(Dimethylamino)-1-(thiophen-3-yl)propan-1-ol

There total 3 articles about 3-(Dimethylamino)-1-(thiophen-3-yl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14994-02-6
3-(dimethylamino)-1-(thiophen-3-yl)propan-1-one hydrochloride

: 116817-84-6
α-[2-(Dimethylamino)ethyl]-3-thiophene methanol

Guidance literature:

Reference yield:

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 116817-84-6
α-[2-(Dimethylamino)ethyl]-3-thiophene methanol

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / ethanol

2: aq. K₂CO₃; NaBH₄ / methanol

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; In methanol; ethanol; 1: Mannich reaction;
DOI:10.1016/j.bmcl.2003.08.079