N-triisopropylsilyl-S-difluoromethyl-S-phenylsulfoximine

Base Information

• Chemical Name: N-triisopropylsilyl-S-difluoromethyl-S-phenylsulfoximine
• CAS No.: 1402352-51-5
• Molecular Formula: C₁₆H₂₇F₂NOSSi
• Molecular Weight: 347.545
• Mol file: 1402352-51-5.mol

Synonyms:N-triisopropylsilyl-S-difluoromethyl-S-phenylsulfoximine

Chemical Property of N-triisopropylsilyl-S-difluoromethyl-S-phenylsulfoximine

Chemical Property:

Purity/Quality:

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Technology Process of N-triisopropylsilyl-S-difluoromethyl-S-phenylsulfoximine

There total 1 articles about N-triisopropylsilyl-S-difluoromethyl-S-phenylsulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

triisopropylsilyl chloride (13154-24-0) + (difluoromethyl)(imino)(phenyl)-λ6-sulfanone (1333375-53-3) → N-triisopropylsilyl-S-difluoromethyl-S-phenylsulfoximine (1402352-51-5)

Guidance literature:

(difluoromethyl)(imino)(phenyl)-λ⁶-sulfanone; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

triisopropylsilyl chloride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ja308419a

Reference yield:

N-triisopropylsilyl-S-difluoromethyl-S-phenylsulfoximine (1402352-51-5) + acetophenone (98-86-2) → C24H35F2NO2SSi

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 3h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ja308419a

upstream raw materials:

triisopropylsilyl chloride

(difluoromethyl)(imino)(phenyl)-λ⁶-sulfanone