tert-butyl 3-(2-bromo-4-((hydroxyimino)methyl)phenyl)-3-cyanoazetidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(2-bromo-4-((hydroxyimino)methyl)phenyl)-3-cyanoazetidine-1-carboxylate
CAS No.:1357614-79-9
Molecular Formula:C₁₆H₁₈BrN₃O₃
Molecular Weight:380.241
Hs Code.:

Synonyms:tert-butyl 3-(2-bromo-4-((hydroxyimino)methyl)phenyl)-3-cyanoazetidine-1-carboxylate

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Chemical Property of tert-butyl 3-(2-bromo-4-((hydroxyimino)methyl)phenyl)-3-cyanoazetidine-1-carboxylate

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Technology Process of tert-butyl 3-(2-bromo-4-((hydroxyimino)methyl)phenyl)-3-cyanoazetidine-1-carboxylate

There total 5 articles about tert-butyl 3-(2-bromo-4-((hydroxyimino)methyl)phenyl)-3-cyanoazetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1357614-77-7
3-(2-bromo-4-(dimethoxymethyl)phenyl)azetidine-3-carbonitrile

: 1357614-79-9
tert-butyl 3-(2-bromo-4-((hydroxyimino)methyl)phenyl)-3-cyanoazetidine-1-carboxylate

Guidance literature:: di-tert-butyl dicarbonate; 3-(2-bromo-4-(dimethoxymethyl)phenyl)azetidine-3-carbonitrile; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

With hydroxylamine hydrochloride; In methanol; water; at 20 - 65 ℃; for 1.16667h;

Reference yield:

: C₁₅H₁₉BrN₂O₂

: 1357614-79-9
tert-butyl 3-(2-bromo-4-((hydroxyimino)methyl)phenyl)-3-cyanoazetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 0.5 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

2.2: 1.17 h / 20 - 65 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 81658-88-0
2-bromo-4-(diethoxymethyl)-1-fluorobenzene

: 1357614-79-9
tert-butyl 3-(2-bromo-4-((hydroxyimino)methyl)phenyl)-3-cyanoazetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 20 °C

2.1: 2-Chloroethyl chloroformate / acetonitrile / 3 h / 0 °C / Reflux

3.1: 0.5 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

4.2: 1.17 h / 20 - 65 °C

With potassium hexamethylsilazane; 2-Chloroethyl chloroformate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;