methyl 2-(2-hydroxyethyl)-4,6-dimethoxybenzoate

Base Information

• Chemical Name: methyl 2-(2-hydroxyethyl)-4,6-dimethoxybenzoate
• CAS No.: 1333419-87-6
• Molecular Formula: C₁₂H₁₆O₅
• Molecular Weight: 240.256
• Mol file: 1333419-87-6.mol

Synonyms:methyl 2-(2-hydroxyethyl)-4,6-dimethoxybenzoate

Chemical Property of methyl 2-(2-hydroxyethyl)-4,6-dimethoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(2-hydroxyethyl)-4,6-dimethoxybenzoate

There total 1 articles about methyl 2-(2-hydroxyethyl)-4,6-dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 2-(2-[1-(tert-butyl)-1,1-dimethylsilyl]oxyethyl)-4,6-dimethoxybenzoate (1333419-86-5) → methyl 2-(2-hydroxyethyl)-4,6-dimethoxybenzoate (1333419-87-6)

Guidance literature:

With pyridine hydrogenfluoride; In tetrahydrofuran; acetonitrile; at 0 - 20 ℃; for 5h; Inert atmosphere;

DOI:10.1055/s-0030-1260058

Reference yield: 95.0%

methyl 2-(2-hydroxyethyl)-4,6-dimethoxybenzoate (1333419-87-6) → methyl 2-(2-iodoethyl)-4,6-dimethoxybenzoate (1333419-88-7)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In diethyl ether; acetonitrile; at 0 - 20 ℃; for 1h;

DOI:10.1055/s-0030-1260058

Reference yield:

methyl 2-(2-hydroxyethyl)-4,6-dimethoxybenzoate (1333419-87-6) → zearalenone (17924-92-4,7645-23-0)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 1 h / 0 - 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 - 25 °C / Inert atmosphere

3.1: lithium hydroxide monohydrate / methanol; water / 24 h / 70 °C

3.2: Inert atmosphere

4.1: triphenylphosphine; diethylazodicarboxylate / diethyl ether; benzene / 14 h / 20 °C

5.1: pyridinium p-toluenesulfonate / ethanol / 1 h / 60 °C

6.1: Grubbs catalyst first generation / toluene / 23 h / 80 °C / Inert atmosphere

7.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane; dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

8.1: aluminium(III) iodide; tetra-(n-butyl)ammonium iodide / benzene / 10 °C

With 1H-imidazole; Grubbs catalyst first generation; aluminium(III) iodide; lithium hydroxide monohydrate; potassium tert-butylate; iodine; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; triphenylphosphine; diethylazodicarboxylate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile; benzene; 4.1: Mitsunobu reaction;

DOI:10.1055/s-0030-1260058

upstream raw materials:

methyl 2-(2-[1-(tert-butyl)-1,1-dimethylsilyl]oxyethyl)-4,6-dimethoxybenzoate

Downstream raw materials:

4,6-dimethoxy-2-vinyl-benzoic acid

methyl 2-(2-iodoethyl)-4,6-dimethoxybenzoate

(1S)-1-methyl-5-(tetrahydro-2H-2-pyranyloxy)-9-decenyl 2,4-dimethoxy-6-vinylbenzoate

(1S)-5-hydroxy-1-methyl-9-decenyl 2,4-dimethoxy-6-vinylbenzoate