methyl 2-(2-[1-(tert-butyl)-1,1-dimethylsilyl]oxyethyl)-4,6-dimethoxybenzoate

Base Information

Chemical Name:methyl 2-(2-[1-(tert-butyl)-1,1-dimethylsilyl]oxyethyl)-4,6-dimethoxybenzoate
CAS No.:1333419-86-5
Molecular Formula:C₁₈H₃₀O₅Si
Molecular Weight:354.519
Hs Code.:

Synonyms:methyl 2-(2-[1-(tert-butyl)-1,1-dimethylsilyl]oxyethyl)-4,6-dimethoxybenzoate

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Chemical Property of methyl 2-(2-[1-(tert-butyl)-1,1-dimethylsilyl]oxyethyl)-4,6-dimethoxybenzoate

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Technology Process of methyl 2-(2-[1-(tert-butyl)-1,1-dimethylsilyl]oxyethyl)-4,6-dimethoxybenzoate

There total 3 articles about methyl 2-(2-[1-(tert-butyl)-1,1-dimethylsilyl]oxyethyl)-4,6-dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 37567-78-5
1,5-dimethoxy-1,4-cyclohexadiene

: 74854-49-2
methyl 5-[1-(tert-butyl)-1,1-dimethylsilyl]oxy-2-pentynoate

: 1333419-86-5
methyl 2-(2-[1-(tert-butyl)-1,1-dimethylsilyl]oxyethyl)-4,6-dimethoxybenzoate

Guidance literature:: With N,N-dimethyl-aniline; at 180 ℃; for 48h; sealed tube; neat (no solvent);
DOI:10.1055/s-0030-1260058

Reference yield:

: 78592-82-2
4-(tert-butyldimethylsilyloxy)-1-butyne

: 1333419-86-5
methyl 2-(2-[1-(tert-butyl)-1,1-dimethylsilyl]oxyethyl)-4,6-dimethoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: N,N-dimethyl-aniline / 48 h / 180 °C / sealed tube; neat (no solvent)

With n-butyllithium; N,N-dimethyl-aniline; In tetrahydrofuran; hexane; 2.1: Diels-Alder reaction;
DOI:10.1055/s-0030-1260058

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1333419-86-5
methyl 2-(2-[1-(tert-butyl)-1,1-dimethylsilyl]oxyethyl)-4,6-dimethoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole; dmap / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

3.1: N,N-dimethyl-aniline / 48 h / 180 °C / sealed tube; neat (no solvent)

With 1H-imidazole; dmap; n-butyllithium; N,N-dimethyl-aniline; In tetrahydrofuran; hexane; dichloromethane; 3.1: Diels-Alder reaction;
DOI:10.1055/s-0030-1260058