((2S,4R)-2-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

Base Information

• Chemical Name: ((2S,4R)-2-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane
• CAS No.: 110724-01-1
• Molecular Formula: C₄₅H₄₉ClF₂O₄Si
• Molecular Weight: 755.417
• Mol file: 110724-01-1.mol

Synonyms:((2S,4R)-2-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

Chemical Property of ((2S,4R)-2-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((2S,4R)-2-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane

There total 8 articles about ((2S,4R)-2-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluoro-3-methylbonzoyl chloride (455-84-5) → ((2S,4R)-2-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane (110724-01-1)

Guidance literature:

Multi-step reaction with 5 steps

1: NaOH / H₂O / 0.5 h

2: AlCl₃ / 2 h / 150 °C

3: tetrahydrofuran

4: H₂, conc. HCl / 10percent Pd/C / acetic acid / 1.5 h / 25 °C / 750.06 Torr

5: K₂CO₃, hydroquinone / dimethylsulfoxide / 3 h / 70 °C

With hydrogenchloride; sodium hydroxide; aluminium trichloride; hydrogen; potassium carbonate; hydroquinone; palladium on activated charcoal; In tetrahydrofuran; water; acetic acid; dimethyl sulfoxide;

DOI:10.1021/jm00114a004

Reference yield:

2-chloro-p-cresol (6640-27-3) → ((2S,4R)-2-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane (110724-01-1)

Guidance literature:

Multi-step reaction with 5 steps

1: NaOH / H₂O / 0.5 h

2: AlCl₃ / 2 h / 150 °C

3: tetrahydrofuran

4: H₂, conc. HCl / 10percent Pd/C / acetic acid / 1.5 h / 25 °C / 750.06 Torr

5: K₂CO₃, hydroquinone / dimethylsulfoxide / 3 h / 70 °C

With hydrogenchloride; sodium hydroxide; aluminium trichloride; hydrogen; potassium carbonate; hydroquinone; palladium on activated charcoal; In tetrahydrofuran; water; acetic acid; dimethyl sulfoxide;

DOI:10.1021/jm00114a004

Reference yield:

(3-Chloro-2-hydroxy-5-methyl-phenyl)-(4-fluoro-3-methyl-phenyl)-methanone → ((2S,4R)-2-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-6-methoxy-tetrahydro-pyran-4-yloxy)-tert-butyl-diphenyl-silane (110724-01-1)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran

2: H₂, conc. HCl / 10percent Pd/C / acetic acid / 1.5 h / 25 °C / 750.06 Torr

3: K₂CO₃, hydroquinone / dimethylsulfoxide / 3 h / 70 °C

With hydrogenchloride; hydrogen; potassium carbonate; hydroquinone; palladium on activated charcoal; In tetrahydrofuran; acetic acid; dimethyl sulfoxide;

DOI:10.1021/jm00114a004

upstream raw materials:

2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenol

2(RS)-methoxy-4(R)-(tert-butyldiphenylsilyloxy)-6(S)-(iodomethyl)tetrahydropyran

4-fluoro-3-methylbonzoyl chloride

2-chloro-p-cresol

Downstream raw materials:

Sodium; (3R,5S)-6-{2-[bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxy}-3,5-dihydroxy-hexanoate

(4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-one

(4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-4-hydroxy-tetrahydro-pyran-2-one

(4R,6S)-6-{2-[Bis-(4-fluoro-3-methyl-phenyl)-methyl]-6-chloro-4-methyl-phenoxymethyl}-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-ol