Methyl 2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propanoate

Base Information

• Chemical Name: Methyl 2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propanoate
• CAS No.: 870820-64-7
• Molecular Formula: C₂₅H₃₅NO₅Si
• Molecular Weight: 457.642
• Mol file: 870820-64-7.mol

Synonyms:Methyl 2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propanoate

Chemical Property of Methyl 2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propanoate

There total 3 articles about Methyl 2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyloxycarbonyl-L-serine methyl ester (2766-43-0) + tert-butylchlorodiphenylsilane (58479-61-1) → Methyl 2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propanoate (870820-64-7)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 39h;

DOI:10.1021/jm049884d

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → Methyl 2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propanoate (870820-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂

2: Et₃N; DMAP / CH₂Cl₂

With dmap; triethylamine; In dichloromethane; 1: Acylation / 2: Substitution;

DOI:10.1039/a905809e

Reference yield:

N-tert-butoxycarbonylserine methyl ester (69942-12-7) + tert-butylchlorodiphenylsilane (58479-61-1) → Methyl 2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propanoate (870820-64-7)

Guidance literature:

With dmap; triethylamine; In dichloromethane;

DOI:10.1039/a905809e

upstream raw materials:

N-tert-butoxycarbonylserine methyl ester

tert-butylchlorodiphenylsilane

N-tert-butyloxycarbonyl-L-serine methyl ester

di-tert-butyl dicarbonate

Downstream raw materials:

2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsiloxy)propanol

2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsiloxy)propanal

1,5-bis(tert-butoxycarbonyl)-2-(tert-butyldiphenylsiloxy)methyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine

1,5-bis(tert-butoxycarbonyl)-2-hydroxymethyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine