3,5-Dibromo-4-methylpyridin-2-amine

Base Information

• Chemical Name: 3,5-Dibromo-4-methylpyridin-2-amine
• CAS No.: 3430-29-3
• Molecular Formula: C6H6Br2N2
• Molecular Weight: 265.935
• Hs Code.: 2933399090
• European Community (EC) Number: 674-940-0
• DSSTox Substance ID: DTXSID50355835
• Wikidata: Q72435623
• Mol file: 3430-29-3.mol

Synonyms:3430-29-3;3,5-dibromo-4-methylpyridin-2-amine;2-Amino-3,5-dibromo-4-methylpyridine;2-amino-3,5-dibromo-4-picoline;3,5-dibromo-4-methyl-2-pyridinamine;MFCD01646065;2-PYRIDINAMINE, 3,5-DIBROMO-4-METHYL-;3,5-Dibromo-4-methyl-pyridin-2-ylamine;AC-907/30003028;SCHEMBL2272554;DTXSID50355835;LLGXZSVWYCKUBB-UHFFFAOYSA-N;AKOS002664309;AB09556;AM86882;DS-2699;PS-7331;2-Amine-3,5-Dibromo-4-Methylpyridine;2-amino-3,5-dibromo-4-methyl pyridine;AC-24905;SY008549;A6042;CS-0142062;FT-0646136;3,5-bis(bromanyl)-4-methyl-pyridin-2-amine;I10107;A822158;J-511262

Chemical Property of 3,5-Dibromo-4-methylpyridin-2-amine

Chemical Property:

• Vapor Pressure: 0.00479mmHg at 25°C
• Refractive Index: 1.651
• Boiling Point: 276.5 °C at 760 mmHg
• Flash Point: 121 °C
• PSA: 38.91000
• Density: 1.99 g/cm³
• LogP: 3.07840
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 265.88772
• Heavy Atom Count: 10
• Complexity: 120

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3,5-dibromo-4-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=NC=C1Br)N)Br

Technology Process of 3,5-Dibromo-4-methylpyridin-2-amine

There total 2 articles about 3,5-Dibromo-4-methylpyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2-Amino-4-methylpyridine (695-34-1) → 2-amino-5-bromo-4-methylpyridine (98198-48-2) + 2-amino-3,5-dibromo-4-methylpyridine (3430-29-3) + 2-amino-3-bromo-4-methylpyridine (40073-38-9)

Guidance literature:

With hydrogen bromide; dihydrogen peroxide; at 70 ℃; for 1h; Product distribution;

Reference yield:

2-Amino-4-methylpyridine (695-34-1) → 2-amino-5-bromo-4-methylpyridine (98198-48-2) + 2-amino-3,5-dibromo-4-methylpyridine (3430-29-3)

Guidance literature:

With bromine; In acetic acid; at 20 ℃; for 1h;

Reference yield: 82.0%

Phenylpropargyl aldehyde (2579-22-8) + 2-amino-3,5-dibromo-4-methylpyridine (3430-29-3) → (6,8-dibromo-7-methyl-1H-imidazo[1,2-a]pyridin-3-yl)(phenyl)methanone

Guidance literature:

With [2,2]bipyridinyl; copper(l) iodide; acetic acid; In dichloromethane; at 20 ℃; for 12h; regioselective reaction;

DOI:10.1021/jo501671x

upstream raw materials:

2-Amino-4-methylpyridine

Downstream raw materials:

3,5-dibromo-2-chloro-4-methylpyridine

Refernces

• 1、 Dunn, A. D.,Currie, A.,Hayes, L. E.. "Bromination of Pyridines. II. Bromination of Aminopicolines". . p. 369 - 374. Retrieved 2007/10/02.