2-Amino-3-bromo-4-picoline

Base Information

• Chemical Name: 2-Amino-3-bromo-4-picoline
• CAS No.: 40073-38-9
• Molecular Formula: C6H7 Br N2
• Molecular Weight: 187.039
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10560029
• Wikidata: Q72438690
• Mol file: 40073-38-9.mol

Synonyms:2-Amino-3-bromo-4-picoline;40073-38-9;2-Amino-3-bromo-4-methylpyridine;3-bromo-4-methylpyridin-2-amine;MFCD08061297;3-bromo-4-methyl-2-pyridinamine;3-bromo-4-methyl-pyridin-2-amine;3-bromo-4-methyl-pyridin-2-ylamine;SCHEMBL342510;DTXSID10560029;PDFCXUVNUUYYOI-UHFFFAOYSA-N;3-bromanyl-4-methyl-pyridin-2-amine;AKOS005135836;AC-5164;AM86939;GS-5651;SY103764;CS-0092076;EN300-94995;A824888;Z1198175808

Chemical Property of 2-Amino-3-bromo-4-picoline

Chemical Property:

• Vapor Pressure: 0.0165mmHg at 25°C
• Boiling Point: 255.2oC at 760 mmHg
• PKA: 4.71±0.47(Predicted)
• Flash Point: 108.2oC
• PSA: 38.91000
• Density: 1.593g/cm3
• LogP: 2.31590
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 185.97926
• Heavy Atom Count: 9
• Complexity: 97.1

Purity/Quality:

98%HPLC ^*data from raw suppliers

2-Amino-3-bromo-4-picoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=NC=C1)N)Br

Technology Process of 2-Amino-3-bromo-4-picoline

There total 1 articles about 2-Amino-3-bromo-4-picoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2-Amino-4-methylpyridine (695-34-1) → 2-amino-5-bromo-4-methylpyridine (98198-48-2) + 2-amino-3,5-dibromo-4-methylpyridine (3430-29-3) + 2-amino-3-bromo-4-methylpyridine (40073-38-9)

Guidance literature:

With hydrogen bromide; dihydrogen peroxide; at 70 ℃; for 1h; Product distribution;

Reference yield: 61.0%

2-amino-3-bromo-4-methylpyridine (40073-38-9) + α-bromoacetophenone (70-11-1) → 8-bromo-7-methyl-2-phenylimidazo[1,2-a]pyridine

Guidance literature:

In ethanol; at 160 ℃; for 1h; Microwave irradiation;

Reference yield: 56.0%

furfural (98-01-1) + o-tolyl isocyanide (10468-64-1) + 2-amino-3-bromo-4-methylpyridine (40073-38-9) → 8-bromo-2-(furan-2-yl)-7-methyl-N-(o-tolyl)imidazo[1,2-a]pyridin-3-amine

Guidance literature:

In neat (no solvent); at 160 ℃; Inert atmosphere;

DOI:10.1021/acschemneuro.9b00447

upstream raw materials:

2-Amino-4-methylpyridine

Downstream raw materials:

2-amino-4-methylpyridine-3-carbonitrile

2,3-dibromo-4-methylpyridine

ML 190

Refernces