(R)-2-Hydroxy-2-methyl-3-((R)-toluene-4-sulfinyl)-succinic acid 4-tert-butyl ester 1-ethyl ester

Base Information

Chemical Name:(R)-2-Hydroxy-2-methyl-3-((R)-toluene-4-sulfinyl)-succinic acid 4-tert-butyl ester 1-ethyl ester
CAS No.:75369-69-6
Molecular Formula:C₁₈H₂₆O₆S
Molecular Weight:370.467
Hs Code.:

Synonyms:(R)-2-Hydroxy-2-methyl-3-((R)-toluene-4-sulfinyl)-succinic acid 4-tert-butyl ester 1-ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-Hydroxy-2-methyl-3-((R)-toluene-4-sulfinyl)-succinic acid 4-tert-butyl ester 1-ethyl ester

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Technology Process of (R)-2-Hydroxy-2-methyl-3-((R)-toluene-4-sulfinyl)-succinic acid 4-tert-butyl ester 1-ethyl ester

There total 4 articles about (R)-2-Hydroxy-2-methyl-3-((R)-toluene-4-sulfinyl)-succinic acid 4-tert-butyl ester 1-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 617-35-6
2-oxo-propionic acid ethyl ester

: 58059-08-8
tert-butyl (R)-p-toluenesulfinylacetate

: 75369-69-6
(R)-2-Hydroxy-2-methyl-3-((R)-toluene-4-sulfinyl)-succinic acid 4-tert-butyl ester 1-ethyl ester

Guidance literature:: With tert-butylmagnesium bromide; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/0040-4020(80)80010-X

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 75369-69-6
(R)-2-Hydroxy-2-methyl-3-((R)-toluene-4-sulfinyl)-succinic acid 4-tert-butyl ester 1-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) (iPr)2NMgBr; 2) NH₄Cl / 1) THF, ether, -40 to -35 deg C

2: 80 percent / t-BuMgBr / tetrahydrofuran / -78 °C

With bromomagnesium diisopropylamide; tert-butylmagnesium bromide; ammonium chloride; In tetrahydrofuran;
DOI:10.1016/0040-4020(80)80010-X

Reference yield:

: 824-79-3
sodium 4-methylbenzenesulfinate

: 75369-69-6
(R)-2-Hydroxy-2-methyl-3-((R)-toluene-4-sulfinyl)-succinic acid 4-tert-butyl ester 1-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) thyonyl chloride / 1) 1 h, 0 deg C; 2) ether, pyridine, 2 h, RT

2: 1) (iPr)2NMgBr; 2) NH₄Cl / 1) THF, ether, -40 to -35 deg C

3: 80 percent / t-BuMgBr / tetrahydrofuran / -78 °C

With thionyl chloride; bromomagnesium diisopropylamide; tert-butylmagnesium bromide; ammonium chloride; In tetrahydrofuran;
DOI:10.1016/0040-4020(80)80010-X