1-(2-{4-[2,8-Bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]-chromen-5-yl]-phenoxy}-ethyl)-piperidine

Base Information

Chemical Name:1-(2-{4-[2,8-Bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]-chromen-5-yl]-phenoxy}-ethyl)-piperidine
CAS No.:554430-39-6
Molecular Formula:C₄₁H₅₇NO₅Si₂
Molecular Weight:700.078
Hs Code.:
DSSTox Substance ID:DTXSID90468498

Synonyms:1-(2-{4-[2,8-Bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]-chromen-5-yl]-phenoxy}-ethyl)-piperidine;554430-39-6;SCHEMBL5107981;SCHEMBL14277789;DTXSID90468498;LRNOLDGKTQRRHV-UHFFFAOYSA-N;1-(2-{4-[2,8-Bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-yl]-phenoxy}-ethyl)-piperidine

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Chemical Property of 1-(2-{4-[2,8-Bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]-chromen-5-yl]-phenoxy}-ethyl)-piperidine

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:699.37752699
Heavy Atom Count:49
Complexity:1130

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OC1=CC2=C(C=C1)C3=C(C(O2)C4=CC=C(C=C4)OCCN5CCCCC5)C6=C(C=C(C=C6)O[Si](C)(C)C(C)(C)C)OC3

Technology Process of 1-(2-{4-[2,8-Bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]-chromen-5-yl]-phenoxy}-ethyl)-piperidine

There total 8 articles about 1-(2-{4-[2,8-Bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]-chromen-5-yl]-phenoxy}-ethyl)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 554430-12-5
2-(4-(hydroxy-(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl))-7-(tert-butyldimethylsilyloxy-2H-chromen-3-yl)-5-(tertbutyldimethylsilyloxy)phenol

: 554430-39-6
2,8-bis(tert-butyldimethylsilyloxy)-5-[4-(2-(piperidin-1-yl)ethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]chromene

: 791-28-6
Triphenylphosphine oxide

Guidance literature:: With molecular sieve; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 18h; Product distribution / selectivity;

Reference yield:

: 554430-12-5
2-(4-(hydroxy-(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl))-7-(tert-butyldimethylsilyloxy-2H-chromen-3-yl)-5-(tertbutyldimethylsilyloxy)phenol

: 554430-39-6
2,8-bis(tert-butyldimethylsilyloxy)-5-[4-(2-(piperidin-1-yl)ethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]chromene

Guidance literature:: With hydrogenchloride; In toluene; at 20 ℃; for 0.5h;
DOI:10.1021/jm060353u

Reference yield:

: 553681-47-3
2,8-bis(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-ol

: 103808-68-0
4-[2-(piperidin-1-yl)-ethoxy]-iodobenzene

: 554430-39-6
2,8-bis(tert-butyldimethylsilyloxy)-5-[4-(2-(piperidin-1-yl)ethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]chromene

Guidance literature:: 4-[2-(piperidin-1-yl)-ethoxy]-iodobenzene; With n-butyllithium; In tetrahydrofuran; pentane; at -78 ℃; for 1.08333h;

2,8-bis(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-ol; In tetrahydrofuran; pentane; for 1.16667h;

With hydrogenchloride; In water; toluene; at 20 ℃; for 0.5h; Product distribution / selectivity;