2H-1-Benzopyran-4-methanol, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[4-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-2-hydroxyphenyl]-a-[4-[2-(1-piperidinyl)ethoxy]phenyl]-

Base Information

Chemical Name:2H-1-Benzopyran-4-methanol, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[4-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-2-hydroxyphenyl]-a-[4-[2-(1-piperidinyl)ethoxy]phenyl]-
CAS No.:554430-12-5
Molecular Formula:C41H59NO6Si2
Molecular Weight:718.094
Hs Code.:

2H-1-Benzopyran-4-methanol,
7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[4-[[(1,1-dimethylethyl)dimethyl
silyl]oxy]-2-hydroxyphenyl]-a-[4-[2-(1-piperidinyl)ethoxy]phenyl]-

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Chemical Property of 2H-1-Benzopyran-4-methanol, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[4-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-2-hydroxyphenyl]-a-[4-[2-(1-piperidinyl)ethoxy]phenyl]-

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Technology Process of 2H-1-Benzopyran-4-methanol, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[4-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-2-hydroxyphenyl]-a-[4-[2-(1-piperidinyl)ethoxy]phenyl]-

There total 7 articles about 2H-1-Benzopyran-4-methanol, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[4-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-2-hydroxyphenyl]-a-[4-[2-(1-piperidinyl)ethoxy]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 553681-47-3
2,8-bis(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-ol

: 920-39-8
isopropylmagnesium bromide

: 103808-68-0
4-[2-(piperidin-1-yl)-ethoxy]-iodobenzene

: 554430-12-5
2-(4-(hydroxy-(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl))-7-(tert-butyldimethylsilyloxy-2H-chromen-3-yl)-5-(tertbutyldimethylsilyloxy)phenol

Guidance literature:: isopropylmagnesium bromide; 4-[2-(piperidin-1-yl)-ethoxy]-iodobenzene; In tetrahydrofuran; diethyl ether; at -22 ℃; for 2.08333h;

2,8-bis(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-ol; In tetrahydrofuran; diethyl ether; at -22 ℃; for 18h;

Reference yield:

: 553681-47-3
2,8-bis(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-ol

: 103808-68-0
4-[2-(piperidin-1-yl)-ethoxy]-iodobenzene

: 554430-12-5
2-(4-(hydroxy-(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl))-7-(tert-butyldimethylsilyloxy-2H-chromen-3-yl)-5-(tertbutyldimethylsilyloxy)phenol

Guidance literature:: 4-[2-(piperidin-1-yl)-ethoxy]-iodobenzene; With n-butyllithium; In tetrahydrofuran; pentane; at -78 ℃; for 1h;

2,8-bis(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-ol; In tetrahydrofuran; pentane; at -78 ℃; for 1h;
DOI:10.1021/jm060353u

Reference yield:

: 554430-87-4
2,8-bis(tert-butyl-dimethyl-silyloxy)-11H-chromeno[4,3-c]chromen-5-one

: 554430-12-5
2-(4-(hydroxy-(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl))-7-(tert-butyldimethylsilyloxy-2H-chromen-3-yl)-5-(tertbutyldimethylsilyloxy)phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminum hydride / toluene / 5 h / -78 °C

2.1: n-BuLi / tetrahydrofuran; pentane / 1 h / -78 °C

2.2: tetrahydrofuran; pentane / 1 h / -78 °C

With n-butyllithium; diisobutylaluminium hydride; In tetrahydrofuran; toluene; pentane;
DOI:10.1021/jm060353u