POTASSIUM VINYLTRIFLUOROBORATE

Base Information

• Chemical Name: POTASSIUM VINYLTRIFLUOROBORATE
• CAS No.: 13682-77-4
• Molecular Formula: C2H3BF3K
• Molecular Weight: 133.95
• Hs Code.: 29319090
• Mol file: 13682-77-4.mol

Synonyms:Borate(1-),ethenyltrifluoro-, potassium, (T-4)- (9CI);Potassium trifluorovinylborate(7CI,8CI);Potassium (ethenyl)trifluoroborate;Potassium vinyltrifluoroborate;

Chemical Property of POTASSIUM VINYLTRIFLUOROBORATE

Chemical Property:

• Appearance/Colour: White to yellowish powder
• Melting Point: 230°C (dec.)
• Boiling Point: 92.8oC at 760mmHg
• Flash Point: 25.5oC
• PSA: 0.00000
• Density: 1.387g/cm3
• LogP: 1.55900
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Hygroscopic

Purity/Quality:

98% ^*data from raw suppliers

Potassium vinyltrifluoroborate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xi
• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• General Description: Potassium vinyltrifluoroborate is a reagent used in organic synthesis, particularly in the preparation of 2-substituted 2H-chromenes through reactions with salicylaldehydes and secondary amines. It serves as a vinyl donor, enabling the formation of these heterocyclic compounds under mild conditions in dimethylformamide (DMF). The resulting chromene derivatives, obtained in moderate to high yields, exhibit potential biological activity, such as TGF-β receptor inhibition. The compound's utility is supported by characterization techniques, including NMR and mass spectrometry, confirming its role in efficient and selective transformations.

Refernces

Synthesis of 2-substituted 2H-chromenes using potassium vinyltrifluoroborates

10.1016/j.tetlet.2008.01.008

The research focuses on the synthesis of 2-substituted 2H-chromenes, which are important oxygenated heterocyclic compounds with potential applications as inhibitors for TGF-b receptors. The synthesis is achieved using potassium vinyltrifluoroborates and salicylaldehyde in the presence of secondary amines, specifically dibenzylamine, at 80°C in dimethylformamide (DMF). The reactants include various substituted salicylaldehydes and potassium vinylboronic acids. The products, 2-substituted 2H-chromene derivatives, are obtained with yields ranging from 51% to 90%. The analyses used to characterize the synthesized compounds include thin layer chromatography, 1H NMR, 13C NMR, and high-resolution mass spectrometry, which confirm the purity and structure of the products.