(S)-(-)-1-[1-(tert-butyldiphenylsilyloxymethyl)-2-(3,4-dimethoxyphenyl)ethyl]pyrrolidine-2,5-dione

Base Information

Chemical Name:(S)-(-)-1-[1-(tert-butyldiphenylsilyloxymethyl)-2-(3,4-dimethoxyphenyl)ethyl]pyrrolidine-2,5-dione
CAS No.:336607-98-8
Molecular Formula:C₃₁H₃₇NO₅Si
Molecular Weight:531.724
Hs Code.:

Synonyms:(S)-(-)-1-[1-(tert-butyldiphenylsilyloxymethyl)-2-(3,4-dimethoxyphenyl)ethyl]pyrrolidine-2,5-dione

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Chemical Property of (S)-(-)-1-[1-(tert-butyldiphenylsilyloxymethyl)-2-(3,4-dimethoxyphenyl)ethyl]pyrrolidine-2,5-dione

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Technology Process of (S)-(-)-1-[1-(tert-butyldiphenylsilyloxymethyl)-2-(3,4-dimethoxyphenyl)ethyl]pyrrolidine-2,5-dione

There total 8 articles about (S)-(-)-1-[1-(tert-butyldiphenylsilyloxymethyl)-2-(3,4-dimethoxyphenyl)ethyl]pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 108-30-5
succinic acid anhydride

: 336607-96-6
(S)-(-)-1-(tert-butyldiphenylsilyloxymethyl)-2-(3,4-dimethoxyphenyl)ethylamine

: 336607-98-8
(S)-(-)-1-[1-(tert-butyldiphenylsilyloxymethyl)-2-(3,4-dimethoxyphenyl)ethyl]pyrrolidine-2,5-dione

Guidance literature:: succinic acid anhydride; (S)-(-)-1-(tert-butyldiphenylsilyloxymethyl)-2-(3,4-dimethoxyphenyl)ethylamine;

With sodium acetate; acetic anhydride;
DOI:10.1016/S0040-4039(00)02319-4

Reference yield:

: 32161-30-1
(S)-3,4-dimethoxyphenylalanine

: 336607-98-8
(S)-(-)-1-[1-(tert-butyldiphenylsilyloxymethyl)-2-(3,4-dimethoxyphenyl)ethyl]pyrrolidine-2,5-dione

Guidance literature:: Multi-step reaction with 6 steps

2.1: 92 percent

3.1: 87 percent / LiAlH₄

4.1: 95 percent

5.1: 86 percent / TFA

6.2: 75 percent / Ac₂O; NaOAc

With lithium aluminium tetrahydride; trifluoroacetic acid;
DOI:10.1016/S0040-4039(00)02319-4

Reference yield:

: 105779-71-3
(S)-(-)-[2-(3,4-dimethoxyphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester

: 336607-98-8
(S)-(-)-1-[1-(tert-butyldiphenylsilyloxymethyl)-2-(3,4-dimethoxyphenyl)ethyl]pyrrolidine-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / imidazole / CH₂Cl₂ / 18 h / 20 °C

2: 86 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / 20 °C

3: diethyl ether / 16 h / Heating

4: 3.9 g / NaOAc; Ac₂O / 1 h / 85 °C

With 1H-imidazole; sodium acetate; acetic anhydride; trifluoroacetic acid; In diethyl ether; dichloromethane;
DOI:10.1021/jo051584w