1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-ethynyl-1H-pyrimidine-2,4-dione

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Chemical Name:1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-ethynyl-1H-pyrimidine-2,4-dione
CAS No.:906794-96-5
Molecular Formula:C₄₆H₄₄N₂O₅Si
Molecular Weight:732.951
Hs Code.:

1-[4-(<i>tert</i>-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-ethynyl-1<i>H</i>-pyrimidine-2,4-dione

Synonyms:1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-ethynyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-ethynyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-ethynyl-1H-pyrimidine-2,4-dione

There total 4 articles about 1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-ethynyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 910040-51-6
1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-trimethylsilanylethynyl-1H-pyrimidine-2,4-dione

: 906794-96-5
1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-ethynyl-1H-pyrimidine-2,4-dione

Guidance literature:: With methanol; sodium methylate;
DOI:10.1081/NCN-200060046

Reference yield:

: 906794-95-4
1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-iodo-1H-pyrimidine-2,4-dione

: 906794-96-5
1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-ethynyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / TEA / (Ph₃P)4Pd; CuI / dimethylformamide

2: 77 percent / sodium methoxide; methanol

With methanol; TEA; sodium methylate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; 1: Sonogashira cross-coupling;
DOI:10.1081/NCN-200060046

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 906794-96-5
1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-ethynyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / imidazole / dimethylformamide

2: 79 percent / TEA / (Ph₃P)4Pd; CuI / dimethylformamide

3: 77 percent / sodium methoxide; methanol

With 1H-imidazole; methanol; TEA; sodium methylate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; 2: Sonogashira cross-coupling;
DOI:10.1081/NCN-200060046