(2R,3R,4R)-2-ethyl 4-methyl 5-oxo-3-phenyltetrahydrofuran-2,4-dicarboxylate

Base Information

Chemical Name:(2R,3R,4R)-2-ethyl 4-methyl 5-oxo-3-phenyltetrahydrofuran-2,4-dicarboxylate
CAS No.:1373610-47-9
Molecular Formula:C₁₅H₁₆O₆
Molecular Weight:292.288
Hs Code.:

Synonyms:(2R,3R,4R)-2-ethyl 4-methyl 5-oxo-3-phenyltetrahydrofuran-2,4-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,4R)-2-ethyl 4-methyl 5-oxo-3-phenyltetrahydrofuran-2,4-dicarboxylate

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Technology Process of (2R,3R,4R)-2-ethyl 4-methyl 5-oxo-3-phenyltetrahydrofuran-2,4-dicarboxylate

There total 4 articles about (2R,3R,4R)-2-ethyl 4-methyl 5-oxo-3-phenyltetrahydrofuran-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1373610-31-1
1-ethyl 3,3-dimethyl 1-oxo-2-phenylpropane-1,3,3-tricarboxylate

: 1373610-47-9
(2R,3R,4R)-2-ethyl 4-methyl 5-oxo-3-phenyltetrahydrofuran-2,4-dicarboxylate

Guidance literature:: With formic acid; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; C₄₀H₃₂N₂O₂S; triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 16h; Reagent/catalyst; Inert atmosphere;
DOI:10.1021/ja3102709

Reference yield: 92.0%

: 1373610-31-1
1-ethyl 3,3-dimethyl 1-oxo-2-phenylpropane-1,3,3-tricarboxylate

: 1373610-47-9
(2R,3R,4R)-2-ethyl 4-methyl 5-oxo-3-phenyltetrahydrofuran-2,4-dicarboxylate

: (2S,3S,4S)-2-ethyl 4-methyl 5-oxo-3-phenyltetrahydrofuran-2,4-dicarboxylate

Guidance literature:: With formic acid; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; C₄₀H₃₂N₂O₂S; triethylamine; In N,N-dimethyl-formamide; at 20 - 70 ℃; for 16.5h; optical yield given as %ee; stereoselective reaction; Inert atmosphere; Resolution of racemate;
DOI:10.1021/ja3027136

Reference yield:

: 1373610-31-1
1-ethyl 3,3-dimethyl 1-oxo-2-phenylpropane-1,3,3-tricarboxylate

: 1373610-47-9
(2R,3R,4R)-2-ethyl 4-methyl 5-oxo-3-phenyltetrahydrofuran-2,4-dicarboxylate

: C₁₅H₁₆O₆

Guidance literature:: With formic acid; C₄₀H₃₂N₂O₂S; [RuCl₂(p-cymene)]₂; triethylamine; In N,N-dimethyl-formamide; at 75 ℃; stereoselective reaction;
DOI:10.1021/jacs.5b00787