1-ethyl 3,3-dimethyl 1-oxo-2-phenylpropane-1,3,3-tricarboxylate

Base Information

• Chemical Name: 1-ethyl 3,3-dimethyl 1-oxo-2-phenylpropane-1,3,3-tricarboxylate
• CAS No.: 1373610-31-1
• Molecular Formula: C₁₆H₁₈O₇
• Molecular Weight: 322.315
• Mol file: 1373610-31-1.mol

Synonyms:1-ethyl 3,3-dimethyl 1-oxo-2-phenylpropane-1,3,3-tricarboxylate

Chemical Property of 1-ethyl 3,3-dimethyl 1-oxo-2-phenylpropane-1,3,3-tricarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-ethyl 3,3-dimethyl 1-oxo-2-phenylpropane-1,3,3-tricarboxylate

There total 1 articles about 1-ethyl 3,3-dimethyl 1-oxo-2-phenylpropane-1,3,3-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

glyoxylic acid ethyl ester (924-44-7) + dimethyl 2-benzylidenepropanedioate (6626-84-2) → 1-ethyl 3,3-dimethyl 1-oxo-2-phenylpropane-1,3,3-tricarboxylate (1373610-31-1)

Guidance literature:

With 2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; triethylamine; In toluene; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ja3027136

Reference yield: 92.0%

1-ethyl 3,3-dimethyl 1-oxo-2-phenylpropane-1,3,3-tricarboxylate (1373610-31-1) → (2R,3R,4R)-2-ethyl 4-methyl 5-oxo-3-phenyltetrahydrofuran-2,4-dicarboxylate (1373610-47-9)

Guidance literature:

With formic acid; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; C₄₀H₃₂N₂O₂S; triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 16h; Reagent/catalyst; Inert atmosphere;

DOI:10.1021/ja3102709

Reference yield: 92.0%

1-ethyl 3,3-dimethyl 1-oxo-2-phenylpropane-1,3,3-tricarboxylate (1373610-31-1) → (2R,3R,4R)-2-ethyl 4-methyl 5-oxo-3-phenyltetrahydrofuran-2,4-dicarboxylate (1373610-47-9) + (2S,3S,4S)-2-ethyl 4-methyl 5-oxo-3-phenyltetrahydrofuran-2,4-dicarboxylate

Guidance literature:

With formic acid; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; C₄₀H₃₂N₂O₂S; triethylamine; In N,N-dimethyl-formamide; at 20 - 70 ℃; for 16.5h; optical yield given as %ee; stereoselective reaction; Inert atmosphere; Resolution of racemate;

DOI:10.1021/ja3027136

upstream raw materials:

glyoxylic acid ethyl ester

dimethyl 2-benzylidenepropanedioate

Downstream raw materials:

(2R,3R,4R)-2-ethyl 4-methyl 5-oxo-3-phenyltetrahydrofuran-2,4-dicarboxylate

C₁₈H₂₀O₆

C₁₃H₁₄O₄

C₁₄H₁₄O₄