Dibenzofuran-3-sulfonyl chloride

Base Information

• Chemical Name: Dibenzofuran-3-sulfonyl chloride
• CAS No.: 42138-14-7
• Molecular Formula: C12H7ClO3S
• Molecular Weight: 266.705
• Hs Code.: 2932999099
• Mol file: 42138-14-7.mol

Synonyms:3-Dibenzofuransulfonylchloride;

Chemical Property of Dibenzofuran-3-sulfonyl chloride

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.694
• Boiling Point: 420.528 °C at 760 mmHg
• Flash Point: 208.128 °C
• PSA: 55.66000
• Density: 1.506 g/cm³
• LogP: 4.59430
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Dibenzo[b,d]furan-3-sulfonyl chloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Dibenzofuran-3-sulfonyl chloride

There total 8 articles about Dibenzofuran-3-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-aminodibenzofuran (4106-66-5) → dibenzofuran-3-sulphonyl chloride (42138-14-7)

Guidance literature:

3-aminodibenzofuran; With hydrogenchloride; sulfur dioxide; acetic acid; sodium nitrite; In water; acetonitrile; at -5 - 7 ℃; for 1.16667h;

With copper(l) chloride; In water; acetonitrile; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2017.11.027

Reference yield: 80.0%

Dibenzofuran-sulfinsaeure-4 → dibenzofuran-3-sulphonyl chloride (42138-14-7)

Guidance literature:

With chlorine; acetic acid; In water; at 0 - 20 ℃; for 8h;

DOI:10.1016/j.bmcl.2011.11.046

Reference yield:

3-aminodibenzofuran (4106-66-5) + copper dichloride → dibenzofuran-3-sulphonyl chloride (42138-14-7)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; acetic acid; benzene;

upstream raw materials:

3-aminodibenzofuran

dibenzofuran

3-nitrodibenzofuran

Downstream raw materials:

1-(dibenzofuran-3-sulfonylamino)cyclohexanecarboxylic acid ethyl ester

MMP145

C₂₆H₂₉N₃O₆S

C₂₆H₂₃N₃O₆S

Refernces

• 1、 Wu, Yuchuan,Li, Jianchang,Wu, Junjun,Morgan, Paul,Xu, Xin,Rancati, Fabio,Vallese, Stefania,Raveglia, Luca,Hotchandani, Rajeev,Fuller, Nathan,Bard, Joel,Cunningham, Kristina,Fish, Susan,Krykbaev, Rustem,Tam, Steve,Goldman, Samuel J.,Williams, Cara,Mansour, Tarek S.,Saiah, Eddine,Sypek, Joseph,Li, Wei. "Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD)". . p. 138 - 143. Retrieved 2012/02/16.
• 2、 Wei, Li,Jianchang, Li,Yuchuan, Wu,Junjun, Wu,Hotchandani, Rajeev,Cunningham, Kristina,McFadyen, Iain,Bard, Joel,Morgan, Paul,Schlerman, Franklin,Xin, Xu,Tam, Steve,Goldman, Samuel J.,Williams, Cara,Sypek, Joseph,Mansour, Tarek S.. "A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): Discovery of (S)- 2-(8-(Methoxycarbonylamino)dibenzo[b,d]furan- 3-sulfonamido)-3-methylbutanoic acid (MMP408)". supporting information; experimental part. p. 1799 - 1802. Retrieved 2009/12/07.