3-chloro-6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)pyridazine

Base Information

Chemical Name:3-chloro-6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)pyridazine
CAS No.:1219095-58-5
Molecular Formula:C₂₂H₁₂ClF₄N₃O
Molecular Weight:445.803
Hs Code.:

Synonyms:3-chloro-6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)pyridazine

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Chemical Property of 3-chloro-6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)pyridazine

Chemical Property:

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Technology Process of 3-chloro-6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)pyridazine

There total 7 articles about 3-chloro-6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1219095-75-6
6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)-3(2H)-pyridazone

: 1219095-58-5
3-chloro-6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)pyridazine

Guidance literature:: 6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)-3(2H)-pyridazone; With trichlorophosphate; for 1.5h; Reflux;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 850991-69-4
5-methoxy-3-pyridinylboronic acid

: 1219095-58-5
3-chloro-6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1: benzyltrimethylammonium chloride; cesium fluoride / bis-triphenylphosphine-palladium(II) chloride / water; toluene / Reflux

2: Darco_.(R). G-60 / ethyl acetate

3: hydrazine hydrate / ethanol / Reflux

4: trichlorophosphate / 1.5 h / Reflux

With benzyltrimethylammonium chloride; hydrazine hydrate; cesium fluoride; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In ethanol; water; ethyl acetate; toluene;

Reference yield:

: 918418-99-2
ethyl 2,4,6-trifluorophenylglyoxylate

: 1219095-58-5
3-chloro-6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)pyridazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine / dichloromethane / 0 - 20 °C

2.1: isopropylmagnesium chloride / diethyl ether / -78 - 5 °C

2.2: 0.33 h

3.1: benzyltrimethylammonium chloride; cesium fluoride / bis-triphenylphosphine-palladium(II) chloride / water; toluene / Reflux

4.1: Darco_.(R). G-60 / ethyl acetate

5.1: hydrazine hydrate / ethanol / Reflux

6.1: trichlorophosphate / 1.5 h / Reflux

With isopropylmagnesium chloride; benzyltrimethylammonium chloride; hydrazine hydrate; triphenylphosphine; cesium fluoride; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In diethyl ether; ethanol; dichloromethane; water; ethyl acetate; toluene;