6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)-3(2H)-pyridazone

Base Information

Chemical Name:6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)-3(2H)-pyridazone
CAS No.:1219095-75-6
Molecular Formula:C₂₂H₁₃F₄N₃O₂
Molecular Weight:427.358
Hs Code.:

Synonyms:6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)-3(2H)-pyridazone

Suppliers and Price of 6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)-3(2H)-pyridazone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)-3(2H)-pyridazone

Chemical Property:

Purity/Quality:

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Technology Process of 6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)-3(2H)-pyridazone

There total 6 articles about 6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)-3(2H)-pyridazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1219095-74-5
5-(2-fluorophenyl)-5-hydroxy-4-(5-methoxy-3-pyridinyl)-3-(2,4,6-trifluorophenyl)-2(5H)-furanone

: 1219095-75-6
6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)-3(2H)-pyridazone

Guidance literature:: With hydrazine hydrate; In ethanol; Reflux;

Reference yield:

: 850991-69-4
5-methoxy-3-pyridinylboronic acid

: 1219095-75-6
6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)-3(2H)-pyridazone

Guidance literature:: Multi-step reaction with 3 steps

1: benzyltrimethylammonium chloride; cesium fluoride / bis-triphenylphosphine-palladium(II) chloride / water; toluene / Reflux

2: Darco_.(R). G-60 / ethyl acetate

3: hydrazine hydrate / ethanol / Reflux

With benzyltrimethylammonium chloride; hydrazine hydrate; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; In ethanol; water; ethyl acetate; toluene;

Reference yield:

: 918418-99-2
ethyl 2,4,6-trifluorophenylglyoxylate

: 1219095-75-6
6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)-3(2H)-pyridazone

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine / dichloromethane / 0 - 20 °C

2.1: isopropylmagnesium chloride / diethyl ether / -78 - 5 °C

2.2: 0.33 h

3.1: benzyltrimethylammonium chloride; cesium fluoride / bis-triphenylphosphine-palladium(II) chloride / water; toluene / Reflux

4.1: Darco_.(R). G-60 / ethyl acetate

5.1: hydrazine hydrate / ethanol / Reflux

With isopropylmagnesium chloride; benzyltrimethylammonium chloride; hydrazine hydrate; triphenylphosphine; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; In diethyl ether; ethanol; dichloromethane; water; ethyl acetate; toluene;