918418-99-2

Upstream product

• 2367-76-2 2,4,6-trifluorobromobenzene 
• 95-92-1 oxalic acid diethyl ester 
• 372-38-3 1,3,5-trifluorobenzene 
• 75716-82-4 imidazol-1-yl-oxo-acetic acid ethyl ester 

Downstream Products

• 918419-00-8 3,3-dichloro-2-(2,4,6-trifluoro-phenyl)-acrylicacidethylester 
• 1021584-35-9 C₁₇H₁₂F₃NO₄ 
• 1020662-71-8 3,3-dichloro-2-(2,4,6-trifluorophenyl)acryloyl chloride 
• 1192118-92-5 3,3-dichloro-1-(4-methoxy-phenyl)-2-(2,4,6-trifluoro-phenyl)-propenone 
• 1448006-00-5 C₁₇H₁₂ClF₃N₂O 
• 1192118-93-6 1-benzyl-5-chloro-3-(4-methoxy-phenyl)-4-(2,4,6-trifluoro-phenyl)-1H-pyrazole 
• 1192118-94-7 5-chloro-3-(4-methoxy-phenyl)-4-(2,4,6-trifluoro-phenyl)-1H-pyrazole 
• 1192117-37-5 3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,4,6-trifluoro-phenyl)-1H-pyrazole 
• 1192117-64-8 3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,6-difluoro-4-methoxy-phenyl)-1H-pyrazole 
• 1219095-72-3 4-bromo-5-(2-fluorophenyl)-3-(2,4,6-trifluorophenyl)-2(5H)-furanone 
• 1219095-73-4 5-(2-fluorophenyl)-4-(5-methoxy-3-pyridinyl)-3-(2,4,6-trifluorophenyl)-2(5H)-furanone 
• 1219095-75-6 6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)-3(2H)-pyridazone 
• 1219095-58-5 3-chloro-6-(2-fluorophenyl)-5-(5-methoxy-3-pyridinyl)-4-(2,4,6-trifluorophenyl)pyridazine 
• 1219095-74-5 5-(2-fluorophenyl)-5-hydroxy-4-(5-methoxy-3-pyridinyl)-3-(2,4,6-trifluorophenyl)-2(5H)-furanone 

Relevant academic research and scientific papers

Synthesis of tetrasubstituted pyrazoles through different cyclization strategies; Isosteres of imidazole fungicides

Formerly unknown 3-chloro-4,5-diaryl-1-methylpyrazoles have been prepared through two different synthesis pathways, one of which starts from 2,3-diarylacrylonitriles, the second from 3,3-dichloro-1,2-diarylpropenones. Both approaches rely on the cyclocondensation of diarylated three-carbon synthons with hydrazine derivatives and possess some unique features. One route uses a cyclization reaction, during which a chlorine atom is directly installed at the pyrazole ring that normally would be introduced in subsequent halogenation steps. The second pathway applies the Sandmeyer reaction to introduce this chloro substituent; an approach that is rarely described at the pyrazole nucleus. The obtained tetrasubstituted pyrazoles are isosteres of highly active imidazole fungicides and show good control of Uncinula necator (grape powdery mildew). Georg Thieme Verlag Stuttgart New York.

A new Knoevenagel-type synthesis of fully substituted γ- hydroxybutenolides

The synthesis of fully substituted γ-hydroxybutenolides is possible by a Knoevenagel-type ring condensation of α-methyleneketones and α-ketoesters under basic conditions. This novel transformation allowed the preparation of di-aryl/heteroaryl substituted hydroxyfuranones, such as 20 and 27, which are important intermediates for pyridazine fungicides. As it turned out, a whole range of different substituents, such as alkyl, cycloalkyl, aryl, heteroaryl and ester groups could be linked to the butenolide scaffold, demonstrating the broad scope of the novel cyclization.

FUNGICIDAL PYRIDAZINES

Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein R1, R2, R3, R4, X, Y and m are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

NOVEL PYRAZOLE DERIVATIVES

The present invention relates tonovel pyrazolederivatives of Formula (I) as active ingredients which have microbiocidal activity, in particular fungicidal activity: wherein R1 is C1-C4 alkyl or C1-C haloalkyl; R

Method for Production of Substituted Phenylmalonate Esters, Novel Phenylmalonate Esters and Use Thereof

A process for preparing substituted phenylmalonic esters of the formula in which R is alkyl and Q is halogen, alkyl, alkoxy, haloalkyl or haloalkoxy and the index m is an integer from 1 to 5, where the groups Q can be identical or different if the index m is greater than 1, comprising steps A), B) and C): A) reaction of compounds of the formula II, in which the variables are as defined for formula I to give compounds of the formula III, B) conversion of the compounds of the formula III into ketals of the formula IV in which R′ is C1-C4-alkyl or benzyl, C) hydrolysis of the compounds of the formula IV to give compounds of the formula I; novel phenylmalonic ester derivatives, and their use as intermediates.