Technology Process of 4-methyl-1-{4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid ethyl ester
There total 10 articles about 4-methyl-1-{4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 65 - 70 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: nitric acid / sulfuric acid / 0.5 h / 0 - 5 °C
2.1: tin(II) chloride dihdyrate / hydrogenchloride / 0.25 h / 0 - 65 °C
3.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 - 5 °C
3.2: 0.5 h / 60 - 65 °C
4.1: sodium hydroxide; potassium permanganate / 1,4-dioxane; water / 2 h / 80 °C
5.1: dicyclohexyl-carbodiimide; 1-hydroxybenzotriazol-hydrate / N,N-dimethyl-formamide / 2 h / 130 - 135 °C
6.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 45 °C
7.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 65 - 70 °C
With
hydrogenchloride; potassium permanganate; thionyl chloride; tin(II) chloride dihdyrate; nitric acid; potassium carbonate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; sodium hydroxide; sodium nitrite;
In
1,4-dioxane; hydrogenchloride; dichloromethane; sulfuric acid; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0.5 h / -5 - 0 °C
2.1: nitric acid / sulfuric acid / 0.5 h / 0 - 5 °C
3.1: tin(II) chloride dihdyrate / hydrogenchloride / 0.25 h / 0 - 65 °C
4.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 - 5 °C
4.2: 0.5 h / 60 - 65 °C
5.1: sodium hydroxide; potassium permanganate / 1,4-dioxane; water / 2 h / 80 °C
6.1: dicyclohexyl-carbodiimide; 1-hydroxybenzotriazol-hydrate / N,N-dimethyl-formamide / 2 h / 130 - 135 °C
7.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 45 °C
8.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 65 - 70 °C
With
hydrogenchloride; aluminum (III) chloride; potassium permanganate; thionyl chloride; tin(II) chloride dihdyrate; nitric acid; potassium carbonate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; sodium hydroxide; sodium nitrite;
In
1,4-dioxane; hydrogenchloride; dichloromethane; sulfuric acid; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
