1-{4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid

Base Information

Chemical Name:1-{4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid
CAS No.:1403232-15-4
Molecular Formula:C₂₈H₃₂ClN₃O₃
Molecular Weight:494.033
Hs Code.:

Synonyms:1-{4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid

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Chemical Property of 1-{4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid

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Technology Process of 1-{4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid

There total 11 articles about 1-{4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403234-00-3
4-methyl-1-{4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid ethyl ester

: 1403232-15-4
1-{4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid

Guidance literature:: With water; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; ethanol; at 80 ℃; for 2h;

Reference yield:

: 18594-05-3
4-cyclohexylacetophenone

: 1403232-15-4
1-{4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: nitric acid / sulfuric acid / 0.5 h / 0 - 5 °C

2.1: tin(II) chloride dihdyrate / hydrogenchloride / 0.25 h / 0 - 65 °C

3.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 - 5 °C

3.2: 0.5 h / 60 - 65 °C

4.1: sodium hydroxide; potassium permanganate / 1,4-dioxane; water / 2 h / 80 °C

5.1: dicyclohexyl-carbodiimide; 1-hydroxybenzotriazol-hydrate / N,N-dimethyl-formamide / 2 h / 130 - 135 °C

6.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 45 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 65 - 70 °C

8.1: sodium hydroxide; potassium hydroxide; water / ethanol; tetrahydrofuran / 2 h / 80 °C

With hydrogenchloride; potassium permanganate; thionyl chloride; tin(II) chloride dihdyrate; water; nitric acid; potassium carbonate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; potassium hydroxide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; hydrogenchloride; ethanol; dichloromethane; sulfuric acid; water; N,N-dimethyl-formamide;

Reference yield:

: 827-52-1,5379-26-0
1-phenyl-1-cyclohexane

: 1403232-15-4
1-{4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}-4-methylpiperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0.5 h / -5 - 0 °C

2.1: nitric acid / sulfuric acid / 0.5 h / 0 - 5 °C

3.1: tin(II) chloride dihdyrate / hydrogenchloride / 0.25 h / 0 - 65 °C

4.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 - 5 °C

4.2: 0.5 h / 60 - 65 °C

5.1: sodium hydroxide; potassium permanganate / 1,4-dioxane; water / 2 h / 80 °C

6.1: dicyclohexyl-carbodiimide; 1-hydroxybenzotriazol-hydrate / N,N-dimethyl-formamide / 2 h / 130 - 135 °C

7.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 45 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 65 - 70 °C

9.1: sodium hydroxide; potassium hydroxide; water / ethanol; tetrahydrofuran / 2 h / 80 °C

With hydrogenchloride; aluminum (III) chloride; potassium permanganate; thionyl chloride; tin(II) chloride dihdyrate; water; nitric acid; potassium carbonate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; potassium hydroxide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; hydrogenchloride; ethanol; dichloromethane; sulfuric acid; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;