5-(3-chloro-4-cyclohexylphenyl)-3-(4-chloromethylphenyl)-[1,2,4]-oxadiazole

Base Information

Chemical Name:5-(3-chloro-4-cyclohexylphenyl)-3-(4-chloromethylphenyl)-[1,2,4]-oxadiazole
CAS No.:1403233-99-7
Molecular Formula:C₂₁H₂₀Cl₂N₂O
Molecular Weight:387.309
Hs Code.:

Synonyms:5-(3-chloro-4-cyclohexylphenyl)-3-(4-chloromethylphenyl)-[1,2,4]-oxadiazole

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Chemical Property of 5-(3-chloro-4-cyclohexylphenyl)-3-(4-chloromethylphenyl)-[1,2,4]-oxadiazole

Chemical Property:

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Technology Process of 5-(3-chloro-4-cyclohexylphenyl)-3-(4-chloromethylphenyl)-[1,2,4]-oxadiazole

There total 7 articles about 5-(3-chloro-4-cyclohexylphenyl)-3-(4-chloromethylphenyl)-[1,2,4]-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403233-98-6
{4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]phenyl}methanol

: 1403233-99-7
5-(3-chloro-4-cyclohexylphenyl)-3-(4-chloromethylphenyl)-[1,2,4]-oxadiazole

Guidance literature:: With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 45 ℃; for 1h;

Reference yield:

: 18594-05-3
4-cyclohexylacetophenone

: 1403233-99-7
5-(3-chloro-4-cyclohexylphenyl)-3-(4-chloromethylphenyl)-[1,2,4]-oxadiazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: nitric acid / sulfuric acid / 0.5 h / 0 - 5 °C

2.1: tin(II) chloride dihdyrate / hydrogenchloride / 0.25 h / 0 - 65 °C

3.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 - 5 °C

3.2: 0.5 h / 60 - 65 °C

4.1: sodium hydroxide; potassium permanganate / 1,4-dioxane; water / 2 h / 80 °C

5.1: dicyclohexyl-carbodiimide; 1-hydroxybenzotriazol-hydrate / N,N-dimethyl-formamide / 2 h / 130 - 135 °C

6.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 45 °C

With hydrogenchloride; potassium permanganate; thionyl chloride; tin(II) chloride dihdyrate; nitric acid; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; sodium hydroxide; sodium nitrite; In 1,4-dioxane; hydrogenchloride; dichloromethane; sulfuric acid; water; N,N-dimethyl-formamide;

Reference yield:

: 827-52-1,5379-26-0
1-phenyl-1-cyclohexane

: 1403233-99-7
5-(3-chloro-4-cyclohexylphenyl)-3-(4-chloromethylphenyl)-[1,2,4]-oxadiazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0.5 h / -5 - 0 °C

2.1: nitric acid / sulfuric acid / 0.5 h / 0 - 5 °C

3.1: tin(II) chloride dihdyrate / hydrogenchloride / 0.25 h / 0 - 65 °C

4.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 - 5 °C

4.2: 0.5 h / 60 - 65 °C

5.1: sodium hydroxide; potassium permanganate / 1,4-dioxane; water / 2 h / 80 °C

6.1: dicyclohexyl-carbodiimide; 1-hydroxybenzotriazol-hydrate / N,N-dimethyl-formamide / 2 h / 130 - 135 °C

7.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 45 °C

With hydrogenchloride; aluminum (III) chloride; potassium permanganate; thionyl chloride; tin(II) chloride dihdyrate; nitric acid; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; sodium hydroxide; sodium nitrite; In 1,4-dioxane; hydrogenchloride; dichloromethane; sulfuric acid; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;