N-Benzyloxy-acetimidic acid 5-tert-butoxycarbonylamino-pentyl ester

Base Information

• Chemical Name: N-Benzyloxy-acetimidic acid 5-tert-butoxycarbonylamino-pentyl ester
• CAS No.: 83948-56-5
• Molecular Formula: C₁₉H₃₀N₂O₄
• Molecular Weight: 350.458
• Mol file: 83948-56-5.mol

Synonyms:N-Benzyloxy-acetimidic acid 5-tert-butoxycarbonylamino-pentyl ester

Chemical Property of N-Benzyloxy-acetimidic acid 5-tert-butoxycarbonylamino-pentyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-Benzyloxy-acetimidic acid 5-tert-butoxycarbonylamino-pentyl ester

There total 4 articles about N-Benzyloxy-acetimidic acid 5-tert-butoxycarbonylamino-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

N-benzyloxyacetamide (4797-81-3) + tert-butyl (5-bromopentyl)carbamate (83948-54-3) → N-Benzyloxy-acetimidic acid 5-tert-butoxycarbonylamino-pentyl ester (83948-56-5) + 1-<(tert-Butoxycarbonyl)amino>-5-pentane (83948-51-0)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; for 24h; Heating;

DOI:10.1021/jo00149a005

Reference yield:

5-hydroxypentylamine (2508-29-4) → N-Benzyloxy-acetimidic acid 5-tert-butoxycarbonylamino-pentyl ester (83948-56-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / acetonitrile / 24 h / Ambient temperature

2: 78 percent / PPh₃, CBr₄ / tetrahydrofuran / Ambient temperature; 1.) 2 h, 2.) stirring overnight

3: KI, K₂CO₃ / acetone / 24 h / Heating

With carbon tetrabromide; potassium carbonate; triphenylphosphine; potassium iodide; In tetrahydrofuran; acetone; acetonitrile;

DOI:10.1021/jo00149a005

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → N-Benzyloxy-acetimidic acid 5-tert-butoxycarbonylamino-pentyl ester (83948-56-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / acetonitrile / 24 h / Ambient temperature

2: 78 percent / PPh₃, CBr₄ / tetrahydrofuran / Ambient temperature; 1.) 2 h, 2.) stirring overnight

3: KI, K₂CO₃ / acetone / 24 h / Heating

With carbon tetrabromide; potassium carbonate; triphenylphosphine; potassium iodide; In tetrahydrofuran; acetone; acetonitrile;

DOI:10.1021/jo00149a005

upstream raw materials:

N-benzyloxyacetamide

tert-butyl (5-bromopentyl)carbamate

5-hydroxypentylamine

di-tert-butyl dicarbonate