83948-54-3

Basic information

• Product Name: 5-(T-BOC-AMINO)-1-PENTYL BROMIDE
• Synonyms: 5-(tert-Butoxycarbonylamino)pentyl bromide;N-(tert-Butoxycarbonyl)-1-bromopentan-5-ylamine;1,1-DiMethylethyl (5-broMopentyl)carbaMate;N-(5-BroMopentyl)carbaMic Acid 1,1-DiMethylethyl Ester;tert-Butyl (5-broMopentyl)carbaMate;CarbaMic acid, N-(5-broMopentyl)-, 1,1-diMethylethyl ester;5-(Boc-aMino)pentyl broMide;5-(T-BOC-AMINO)-1-PENTYL BROMIDE
• CAS NO: 83948-54-3
• Molecular Formula: C₁₀H₂₀BrNO₂
• Molecular Weight: 266.18
• Product Categories: All Aliphatics;Aliphatics
• Mol File: 83948-54-3.mol
• Article Data: 23

Chemical Properties

• Melting Point: approx. 35°C
• Boiling Point: 324℃
• Flash Point: 150℃
• Appearance: /
• Density: 1.214
• Vapor Pressure: 0.000243mmHg at 25°C
• Refractive Index: 1.472
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility: Chloroform, Ethyl Acetate, Methanol
• PKA: 12.87±0.46(Predicted)
• CAS DataBase Reference: 5-(T-BOC-AMINO)-1-PENTYL BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(T-BOC-AMINO)-1-PENTYL BROMIDE(83948-54-3)
• EPA Substance Registry System: 5-(T-BOC-AMINO)-1-PENTYL BROMIDE(83948-54-3)

Safety Data

• Hazardous Substances Data: 83948-54-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H20BrNO2/c1-10(2,3)14-9(13)12-8-6-4-5-7-11/h4-8H2,1-3H3,(H,12,13)

Upstream product

• 27219-07-4 5-(N-tert-butyloxycarbonyl)aminopentanoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 51874-27-2 1-amino-5-bromopentane hydrobromide 
• 2508-29-4 5-hydroxypentylamine 
• 26342-08-5 1-Amino-5-bromopentane 
• 216959-34-1 ethyl 2-{[(tert-butoxy)carbonyl]amino}-2-oxoacetate 
• 932403-94-6 N-tert-butyloxycarbonyl N-5-bromopentyl ethyl oxamate 
• 75178-90-4 N-(tert-butyloxycarbonyl)-5-aminopentanol 
• 118811-34-0 5-((tert-butoxycarbonyl)amino)pentyl 4-methylbenzenesulfulfonate 
• 142342-55-0 diethyl {5-[(tert-butoxycarbonyl)amino]pentyl }-propanedioate 

Downstream Products

• 142355-78-0 (S)-2-Benzyloxycarbonylamino-3-[4-(5-tert-butoxycarbonylamino-pentyloxy)-phenyl]-propionic acid 
• 153492-09-2 1-<(tert-Butoxycarbonyl)amino>-5-<(benzyloxy)amino>pentane 
• 932403-99-1 tert-butyl 5,5'-(2,5-dibromo-1,4-phenylene)bis(oxy)bis(pentane-5,1-diyl)dicarbamate 
• 51874-27-2 1-amino-5-bromopentane hydrobromide 
• 83948-56-5 N-Benzyloxy-acetimidic acid 5-tert-butoxycarbonylamino-pentyl ester 
• 83948-51-0 1-<(tert-Butoxycarbonyl)amino>-5-pentane 

Relevant articles and documents

Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor

Mercaptoacetamide histone deacetylase inhibitors are neuroprotective agents that do not exhibit the genotoxicity associated with more commonly used hydroxamate inhibitors. Here, we present the crystal structure of a selective mercaptoacetamide complexed w

Thiol- And Disulfide-Containing Vancomycin Derivatives against Bacterial Resistance and Biofilm Formation

Antibiotic-resistant and biofilm-associated infections constitute a rapidly growing issue. Use of the last-resort antibiotic vancomycin is under threat due to the increasing appearance of vancomycin-resistant bacteria as well as the formation of biofilms. Herein, we report a series of novel vancomycin derivatives carrying thiol- and disulfide-containing moieties. The new compounds exhibited enhanced antibacterial activity against a broad range of bacterial strains, including vancomycin-resistant microbes and Gram-negative bacteria. Moreover, all obtained derivatives demonstrated improved antibiofilm formation activity against VanB-resistant Enterococcus compared to vancomycin. This work establishes a promising strategy for combating drug-resistant bacterial infections or disrupting biofilm formation and advances the knowledge on the structural optimization of antibiotics with sulfur-containing modifications.

ISOINDOLINE DERIVATIVES WHICH BIND TO AN ATP BINDING SITE

The present invention relates to novel probe compounds of formulae I and II defined herein. The present invention also relates to methods of synthesising these novel probe compounds and to their use in assays and screens for determining the binding of a test molecule to the ATP-binding site of a target protein, such as, for example, the Mismatch Repair (MMR) component proteins PMS2 and MLH1, or for determining the location and/or quantity of such target proteins in a biological sample.