3-([5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl]methoxy)benzaldehyde

Base Information

Chemical Name:3-([5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl]methoxy)benzaldehyde
CAS No.:174258-10-7
Molecular Formula:C₁₉H₁₄F₃NO₃
Molecular Weight:361.32
Hs Code.:

Synonyms:3-([5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl]methoxy)benzaldehyde

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Chemical Property of 3-([5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl]methoxy)benzaldehyde

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Technology Process of 3-([5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl]methoxy)benzaldehyde

There total 5 articles about 3-([5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl]methoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 100-83-4
meta-hydroxybenzaldehyde

: 174258-39-0
4-(chloromethyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

: 174258-10-7
3-([5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl]methoxy)benzaldehyde

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;
DOI:10.1021/jm990476x

Reference yield: 65.0%

: 174258-10-7
3-([5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl]methoxy)benzaldehyde

Guidance literature:

Reference yield:

: 475480-98-9
4,5-dimethyl-2-(4-trifluoromethylphenyl)-oxazole 3-oxide

: 174258-10-7
3-([5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl]methoxy)benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

2: 65 percent / K₂CO₃ / dimethylformamide / 3 h / 80 °C

With potassium carbonate; trichlorophosphate; In chloroform; N,N-dimethyl-formamide; 1: Chlorination / 2: Alkylation;
DOI:10.1021/jm990476x